Evidence map›Paper›PMID 35501649›Full record

ArticleBulletin of experimental biology and medicine2022

Panel of Candidate Genes to Predict the Survival of Patients with Clear Cell Renal Cancer on the Basis of Gene Expression Regulated by HIF1α/HIF2α.

N V Apanovich, P V Apanovich, D J Mansorunov, A Yu Kuzevanova, A A Korotaeva, T A Bogush, V B Matveev, A V Karpukhin

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

N V ApanovichN. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia.
P V ApanovichN. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia.
D J MansorunovN. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia.
A Yu KuzevanovaN. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia.
A A KorotaevaN. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia.
T A BogushN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
V B MatveevN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
A V KarpukhinN. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia. karpukhin@med-gen.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The detection of genes related to the lifetime of patients with clear cell renal cancer provides information on the mechanisms of the tumor development and can be the basis for creating approaches to predict patient survival. In this paper, the expression of genes regulated by the HIF2α transcriptional factor was studied. Based on the results obtained here and previously identified genes regulated by the transcriptional factor HIF1α, a new panel of 6 genes, including the BAP1 gene, was proposed. Expression of genes of this panel allows predicting the survival of patients with clear cell renal cancer with high sensitivity (93%), specificity (96%), and relative risk (21.5). After verification, the application of this panel can be useful for personalized treatment of patients with clear cell renal cancer, which will increase the effectiveness of therapy.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsBasic Helix-Loop-Helix ProteinsGene ExpressionHumansHypoxia-Inducible Factor 1, alpha SubunitBasic Helix-Loop-Helix ProteinsHypoxia-Inducible Factor 1, alpha Subunitclear cell renal cancerexpression of genes regulated by the HIF1α and HIF2αsurvival prognosis

Identifiers

PMID35501649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.