Evidence map›Paper›PMID 35501640›Full record

ArticleBulletin of experimental biology and medicine2022

Transcriptional Activity of Some Genes Involved in Apoptosis in Patients with Vulvar Lichen Sclerosus.

E A Klimov, V V Sobolev, N A Batashkov, Z G Kokaeva, A V Tretiakov, Z A Nevozinskaya, I M Korsunskaya, T N Sukhova, O E Evina, A Z Khashukoeva

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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

E A KlimovFaculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
V V SobolevUniversity Diagnostic Laboratory, Moscow, Russia.
N A BatashkovFaculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
Z G KokaevaFaculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
A V TretiakovFaculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia.
Z A NevozinskayaMoscow Scientific and Practical Center for Dermatovenereology and Cosmetology, Moscow, Russia.
I M KorsunskayaCenter of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia. marykor@bk.ru.
T N SukhovaPirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation, Moscow, Russia.
O E EvinaMEDSI, Moscow, Russia.
A Z KhashukoevaPirogov Russian National Research Medical University, Ministry of the Health of the Russian Federation, Moscow, Russia.
Lomonosov Moscow State University · RUPirogov Russian National Research Medical University · RUConsultative and Diagnostic Center · RUCenter for Theoretical Problems of Physicochemical Pharmacology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lichen sclerosus of the vulva is a common, but poorly studied disease. We assessed the level of transcriptional activity of APAF1, BAX, BCL2, BIRC5, CCND1, DAPK1, MCL1, and MYC genes encoding products that control apoptosis in the samples of tissues affected by vulvar lichen sclerosus and adjacent control tissues (n=24). Analysis of transcriptional activity was performed by real-time PCR using specific primers and SYBR Green intercalating dye. After the total group was divided by the presence of the concomitant gynecological diseases, a significant increase in the transcriptional activity of the CCND1 gene was revealed in patients with concomitant uterine fibroids. This may indicate the possible role of the activation of mitosis during tumor initiation.

Indexed as

Lichen Sclerosus et AtrophicusVulvar Lichen SclerosusApoptosisCell Transformation, NeoplasticFemaleHumansVulvaapoptosispolymerase chain reactiontranscriptional gene activityuterine fibroidvulvar lichen sclerosus

Identifiers

PMID35501640
OpenAlexW4225287695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.