Impact of instrumental settings in electrospray ionization ion trap mass spectrometry on the analysis of O-methoxyethyl-O-methyl cellulose: a comprehensive quantitative evaluation.

Sarah Schleicher, Dominik Horoba, Philip Krafzig, Petra Mischnick

Open access · hybridAbstract read

In one paragraph

Article in Analytical and bioanalytical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.4field-weighted citation impact, top 45% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Potential of ion mobility mass spectrometry in cellulose ether analysis: substitution pattern of hydroxyethyl celluloses.Analytical and bioanalytical chemistry · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sarah SchleicherInstitute of Food Chemistry, Technische Universität Braunschweig, Schleinitzstr 20, 38106, Braunschweig, Germany.

Dominik HorobaInstitute of Food Chemistry, Technische Universität Braunschweig, Schleinitzstr 20, 38106, Braunschweig, Germany.

Philip KrafzigInstitute of Food Chemistry, Technische Universität Braunschweig, Schleinitzstr 20, 38106, Braunschweig, Germany.

Petra MischnickInstitute of Food Chemistry, Technische Universität Braunschweig, Schleinitzstr 20, 38106, Braunschweig, Germany. p.mischnick@tu-bs.de.ORCID https://orcid.org/0000-0002-8313-3313

Technische Universität Braunschweig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hydroxyethyl substitution along and among the polymer chains of respective cellulose ethers (HEC and HEMC) can be analyzed by ESI-IT-MS after permethylation of the free OH-groups, partial hydrolysis, and mABA labeling. This method requires the correct quantification of the molar ratios of the constituents belonging to a particular degree of polymerization (DP) with respect to their numbers of MeOEt and Me groups without any discrimination along the MS analysis pathway. The influence of the chemistry on the ionization and the impact of the voltages controlling the ion transport (Cap Exit, Octopoles) and the ion storage efficiency (Trap Drive, TD) on a relative quantification were studied using binary equimolar mixtures of cellobiose with increasing number of methoxyethyl and decreasing number of methyl groups (Δ m/z 88, 2× MeOEt). No suppression effects were observed in concentration-dependent measurements. Choice of Cap Exit is especially crucial for low m/z with less MeOEt residues. An equation describing the relationship between Oct 2 DC, m/z, and TD

Indexed as

MethylcelluloseSpectrometry, Mass, Electrospray IonizationCelluloseGas Chromatography-Mass SpectrometryHydrolysisCelluloseMethylcelluloseElectrospray ionization ion trap mass spectrometryHydroxyethyl(methyl)celluloseOligosaccharide ethersQuantitative mass spectrometrySubstituent distribution

Identifiers

PMID35501507

DOI10.1021/ac00072a020

PMCPMC9174117

OpenAlexW4225380754

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.