ArticleJournal of neurology2022
Eye tracking identifies biomarkers in α-synucleinopathies versus progressive supranuclear palsy.
Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06597071 (Use of Oculometric Measures in the Differential Diagnosis of Typical and Atypical Parkinsonian Conditions), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Oculometric Measures in the Differential Diagnosis of Typical and Atypical Parkinsonian Conditions: a Pilot Study
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Naturalistic Eye Movement Tasks in Parkinson's Disease: A Systematic Review.Journal of Parkinson's disease · 2024Pooled it
- Advanced Eye Movement Features Measured by Quantitative Oculography as Candidate Biomarkers for Progressive Supranuclear Palsy.Diagnostics (Basel, Switzerland) · 2026Review
- Synucleinopathy-like clinical features and biologically defined synuclein seeding in PSP-Parkinsonism: an imperfect match.NPJ Parkinson's disease · 2026Article
- Eye tracking as a digital biomarker in neurodegenerative diseases.Journal of neurology · 2026Review
- From clinical phenotypes to molecular precision: multimodal biomarkers for progressive supranuclear palsy.Frontiers in neuroscience · 2026Review
- Collection of the digital data from the neurological examination.NPJ digital medicine · 2025Article
- Joint examination of reflexive vertical saccades and small involuntary fixational saccades improves the classification of patients with progressive supranuclear palsy (PSP): a ROC study.Experimental brain research · 2025Article
- Saccade, pupil, and blink abnormalities in prodromal and manifest alpha-synucleinopathies.Journal of Parkinson's disease · 2025Article
- Autonomic dysfunction in progressive supranuclear Palsy: A retrospective study.Clinical parkinsonism & related disorders · 2025Article
- Cognitive load and visual attention assessment using physiological eye tracking measures in multimedia learning.PloS one · 2025Article
- Eye movement and pupillary response abnormalities measured using virtual reality as biomarkers in the diagnosis of early-stage Parkinson's disease.Frontiers in neurology · 2025Article
- Saccade and pupil changes in children recovering from opsoclonus-myoclonus ataxia syndrome reveal midbrain alterations in oculomotor circuits.Annals of the Child Neurology Society · 2024Article
- Automated Analysis Pipeline for Extracting Saccade, Pupil, and Blink Parameters Using Video-Based Eye Tracking.Vision (Basel, Switzerland) · 2024Article
- Noradrenergic modulation of saccades in Parkinson's disease.Brain communications · 2024Article
- Distinct eye movement patterns to complex scenes in Alzheimer's disease and Lewy body disease.Frontiers in neuroscience · 2024Article
- Emotion Recognition in Multiple System Atrophy: An Exploratory Eye-Tracking Study.Journal of movement disorders · 2024Article
- Eye-tracking in adult depression: protocol for a systematic review and meta-analysis.BMJ open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 3 countries.
Funding
Abstract
objectivesThis study (1) describes and compares saccade and pupil abnormalities in patients with manifest alpha-synucleinopathies (αSYN: Parkinson's disease (PD), Multiple System Atrophy (MSA)) and a tauopathy (progressive supranuclear palsy (PSP)); (2) determines whether patients with rapid-eye-movement sleep behaviour disorder (RBD), a prodromal stage of αSYN, already have abnormal responses that may indicate a risk for developing PD or MSA.
methodsNinety (46 RBD, 27 PD, 17 MSA) patients with an αSYN, 10 PSP patients, and 132 healthy age-matched controls (CTRL) were examined with a 10-min video-based eye-tracking task (Free Viewing). Participants were free to look anywhere on the screen while saccade and pupil behaviours were measured.
resultsPD, MSA, and PSP spent more time fixating the centre of the screen than CTRL. All patient groups made fewer macro-saccades (> 2
conclusionRBD patients already have discrete but less pronounced saccade abnormalities than PD and MSA patients. Vertical gaze palsy and altered pupil control differentiate PSP from αSYN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.