Evidence map›Paper›PMID 35501454›Full record

ArticleNature plants2022

Noise reduction by upstream open reading frames.

Ho-Wei Wu, Erickson Fajiculay, Jing-Fen Wu, Ching-Cher Sanders Yan, Chao-Ping Hsu, Shu-Hsing Wu

Open access · hybridAbstract read
In one paragraph

Article in Nature plants, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Ho-Wei WuInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-5978-719X
Erickson FajiculayInstitute of Chemistry, Academia Sinica, Taipei, Taiwan.
Jing-Fen WuInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan.
Ching-Cher Sanders YanInstitute of Chemistry, Academia Sinica, Taipei, Taiwan.
Chao-Ping HsuGenome and Systems Biology Degree Program, Academia Sinica and National Taiwan University, Taipei, Taiwan. cherri@sinica.edu.tw.ORCID http://orcid.org/0000-0002-7187-427X
Shu-Hsing WuInstitute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan. shuwu@gate.sinica.edu.tw.ORCID http://orcid.org/0000-0002-7179-3138
National Taiwan University · TWInstitute of Chemistry, Academia Sinica · TWInstitute of Plant and Microbial Biology, Academia Sinica · TWNational Tsing Hua University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene expression is prone to burst production, making it a highly noisy process that requires additional controls. Upstream open reading frames (uORFs) are widely present in the 5' leader sequences of 30-50% of eukaryotic messenger RNAs

Indexed as

PlantsProtein BiosynthesisOpen Reading FramesRNA, MessengerRNA, Messenger

Identifiers

PMID35501454
PMCPMC9122824
OpenAlexW4225262646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.