ArticleNature neuroscience2022
A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice.
Erratum issuedOpen access · greenAbstract read
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Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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27citing papers in PubMed
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27 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- A pontomesencephalic-mesolimbic circuit modulates activity-based anorexia.Science advances · 2026Article
- Beyond Pleasure: Unraveling the Multifaceted Role of Dopamine in Obesity and Metabolic Regulation.Current obesity reports · 2026Review
- Serotonin neurons in the dorsal raphe control food-craving-like behavior during pregnancy in mice.Nature neuroscience · 2026Article
- Neural circuits regulating activity-based anorexia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Comprehensive insights into emerging advances in the Neurobiology of anorexia.Journal of advanced research · 2026Review
- Reduced Ventral Tegmental Area GABA neuron output contributes to hyperactivity in the activity-based anorexia model in female mice.Nature communications · 2025Article
- Integrated single-cell atlases unveil the operation principles of whole-brain 5-HT neuronal subsystems.Science advances · 2025Article
- Lac-Phe induces hypophagia by inhibiting AgRP neurons in mice.Nature metabolism · 2025Article
- Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets.MedComm · 2025Review
- Association Between Stress-Induced Weight Loss and Autophagy-Related Gene Expression in the Hippocampus and Midbrain of Depression Model Mice.Neuropsychopharmacology reports · 2025Article
- Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation.Metabolism: clinical and experimental · 2025Article
- Pharmacotherapeutic strategies for the treatment of anorexia nervosa - novel targets to break a vicious cycle.Expert opinion on pharmacotherapy · 2024Review
- Sex-biased neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behavior.Nature neuroscience · 2024Article
- Role of the Dorsal Raphe Nucleus in Pain Processing.Brain sciences · 2024Review
- Establishing connectivity through microdissections of midbrain stimulation-related neural circuits.Brain : a journal of neurology · 2024Article
- Distinct basal forebrain-originated neural circuits promote homoeostatic feeding and suppress hedonic feeding in male mice.Nature metabolism · 2024Article
- Why Don't You Just Eat? Neuroscience and the Enigma of Eating Disorders.Focus (American Psychiatric Publishing) · 2024Article
- 5-HT Neurons Integrate GABA and Dopamine Inputs to Regulate Meal Initiation.bioRxiv : the preprint server for biology · 2024Article
- A modular organic neuromorphic spiking circuit for retina-inspired sensory coding and neurotransmitter-mediated neural pathways.Nature communications · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
20 authors at 6 institutions in 2 countries.
Xing Cai *Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Hailan Liu *Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Bing FengBrain Glycemic and Metabolism Control Department, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA.
Meng YuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0002-8007-3378
Yang HeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Hesong LiuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Chen LiangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Yongjie YangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Longlong TuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Nan ZhangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Lina WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Na YinChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Junying HanChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Zili YanChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Chunmei WangChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Pingwen XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-9363-4114
Qi WuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Qingchun TongBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-4561-2540
Yanlin HeChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. yanlin.he@pbrc.edu.ORCID 0000-0002-5471-9016
Yong XuChildren's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. yongx@bcm.edu.ORCID 0000-0002-4908-1572
Children's Nutrition Research Center at Baylor College of Medicine · USPennington Biomedical Research Center · USBaylor College of Medicine · USBrown Foundation · USKunming Institute of Zoology · CNUniversity of Illinois Chicago · US
Funding
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5MPilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9MThe role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Jacqueline M Stephens · 2020 to 2026
$18.4MProject 3: Coactivator-dependent hepatic 12h clock coordinates metabolic and stress rhythmsP01DK113954 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI SREEKUMAR, ARUN · 2018 to 2022
$7.9MR01 Application:Genetically Dissecting Cholinergic Signaling in Body Weight Control.R01DK109934 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Benjamin R Arenkiel, Qingchun Tong · 2016 to 2026
$5.4MTestosterone and estrogen signaling pathways in the medial amygdala interact to control energy homeostasisR01DK123098 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XU, PINGWEN · 2020 to 2024
$2.5MHypothalamic Grb10 and body weightR01DK115761 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FRAZER, ALAN, XU, YONG · 2018 to 2021
$2.0M5-HT NEURONS INTEGRATE NEURAL INPUTS TO REGULATE FOOD INTAKER01DK120858 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI TONG, QINGCHUN, XU, YONG · 2020 to 2023
$1.9MNeurobiology for the sex differences in energy balanceR01DK117281 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI XU, YONG · 2018 to 2022
$1.8MA Novel AgRP Neurons to the Dorsal Raphe Circuit in Control of Energy ExpenditureR01DK109194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI WU, QI · 2017 to 2021
$1.8MA direct LH to PVH projection for antagonistic regulation of feedingR01DK114279 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TONG, QINGCHUN · 2018 to 2021
$1.5MMedial amygdala ERα neurocircuits in the regulation of physical activityR00DK107008 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI XU, PINGWEN · 2018 to 2020
$743kNIDDK NIH HHS K01 DK119471NIDDK NIH HHS P01 DK113954NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R00 DK107008NIDDK NIH HHS R01 DK109194NIDDK NIH HHS R01 DK109934NIDDK NIH HHS R01 DK114279NIDDK NIH HHS R01 DK115761NIDDK NIH HHS R01 DK117281NIDDK NIH HHS R01 DK120858NIDDK NIH HHS R01 DK123098NIDDK NIH HHS R56 DK109194NIGMS NIH HHS P20 GM135002NINDS NIH HHS R21 NS108091
Abstract
Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors, including feeding, but less is known about how these circuits may interact. In this study, we found that DA neurons in the mouse ventral tegmental area bidirectionally regulate the activity of 5-HT neurons in the dorsal raphe nucleus (DRN), with weaker stimulation causing DRD2-dependent inhibition and overeating, while stronger stimulation causing DRD1-dependent activation and anorexia. Furthermore, in the activity-based anorexia (ABA) paradigm, which is a mouse model mimicking some clinical features of human anorexia nervosa (AN), we observed a DRD2 to DRD1 shift of DA neurotransmission on 5-HT
Indexed as
DopamineSerotoninAnimalsAnorexiaDopaminergic NeuronsMesencephalonMiceNeuronsDopamineSerotonin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.