ArticleNature communications2022
The barley leaf rust resistance gene Rph3 encodes a predicted membrane protein and is induced upon infection by avirulent pathotypes of Puccinia hordei.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 30 citations in OpenAlex.
- A transmembrane protein confers the Yr26/Yr24/YrCH42/YrG22-mediated stripe rust resistance in wheat.Nature communications · 2026Article
- Streptomyces aheensis sp. nov. and Streptomyces ruilongensis sp. nov. isolated from desert soil in Xinjiang.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Identification of Ubiquitin Genes and Their Expression Patterns inPlants (Basel, Switzerland) · 2026Article
- Predictions of Genes Conferring Resistance toPlants (Basel, Switzerland) · 2025Article
- Foliar disease resistance phenomics of fungal pathogens: image-based approaches for mapping quantitative resistance in cereal germplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Genetic and physical localization of a leaf rust susceptibility gene in barley.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Genetic engineering, including genome editing, for enhancing broad-spectrum disease resistance in crops.Plant communications · 2025Review
- Unveiling the underlying complexities in breeding for disease resistance in crop plants: review.Frontiers in plant science · 2025Review
- Alternative splicing of a potato disease resistance gene maintains homeostasis between growth and immunity.The Plant cell · 2024Article
- Are cereal grasses a single genetic system?Nature plants · 2024Article
- A membrane associated tandem kinase from wild emmer wheat confers broad-spectrum resistance to powdery mildew.Nature communications · 2024Article
- Resistance that stacks up: engineering rust and mildew disease control in the cereal crops wheat and barley.Plant biotechnology journal · 2023Review
- A pathogen-induced putative NAC transcription factor mediates leaf rust resistance in barley.Nature communications · 2023Article
- Genetic mapping of the wheat leaf rust resistance gene Lr19 and development of translocation lines to break its linkage with yellow pigment.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Genome-wide association studies using multi-models and multi-SNP datasets provide new insights into pasmo resistance in flax.Frontiers in plant science · 2023Article
- Mining of long non-coding RNAs with target genes in response to rust based on full-length transcriptome in Kentucky bluegrass.Frontiers in plant science · 2023Article
- Plant Executor Genes.International journal of molecular sciences · 2022Review
- The genetic basis and interaction of genes conferring resistance toFrontiers in plant science · 2022Article
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
Abstract
Leaf rust, caused by Puccinia hordei, is an economically significant disease of barley, but only a few major resistance genes to P. hordei (Rph) have been cloned. In this study, gene Rph3 was isolated by positional cloning and confirmed by mutational analysis and transgenic complementation. The Rph3 gene, which originated from wild barley and was first introgressed into cultivated Egyptian germplasm, encodes a unique predicted transmembrane resistance protein that differs from all known plant disease resistance proteins at the amino acid sequence level. Genetic profiles of diverse accessions indicated limited genetic diversity in Rph3 in domesticated germplasm, and higher diversity in wild barley from the Eastern Mediterranean region. The Rph3 gene was expressed only in interactions with Rph3-avirulent P. hordei isolates, a phenomenon also observed for transcription activator-like effector-dependent genes known as executors conferring resistance to Xanthomonas spp. Like known transmembrane executors such as Bs3 and Xa7, heterologous expression of Rph3 in N. benthamiana induced a cell death response. The isolation of Rph3 highlights convergent evolutionary processes in diverse plant-pathogen interaction systems, where similar defence mechanisms evolved independently in monocots and dicots.
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