Ritalin as a causal perturbation.

Catrina M Hacker, Nicole C Rust

Abstract readComment

In one paragraph

Article in Trends in cognitive sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

Comment on
Methylphenidate as a causal test of translational and basic neural coding hypotheses.2022

5 · Who and what money

Authors and funding

2 authors.

Catrina M HackerDepartment of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: cmhacker@pennmedicine.upenn.edu.

Nicole C RustDepartment of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: nrust@psych.upenn.edu.

Funding

Leveraging visual fidelity to understand the neural mechanisms responsible for remembering images and objectsR01EY032878 · NEI · UNIVERSITY OF PENNSYLVANIA · PI RUST, NICOLE C · 2021 to 2023

$1.3M

NEI NIH HHS R01 EY032878

6 · The paper itself

Abstract

Causal perturbations provide the strongest tests of the relationships between brain mechanism and brain function. In cognitive neuroscience, persuasive causal perturbations are difficult to achieve. In a recent paper, Ni et al. cleverly use the neuropsychiatric drug methylphenidate (Ritalin) to causally test the brain mechanisms that support goal-directed attention.

Indexed as

Attention Deficit Disorder with HyperactivityMethylphenidateAttentionBrainHumansMethylphenidateattentionAttention Deficit Hyperactivity DisordercausalitymethylphenidateRitalin

Identifiers

PMID35501247

DOI10.1016/j.tics.2022.04.002

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.