Evidence map›Paper›PMID 35501130›Full record

ArticleGenome research2022

Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression.

Celine L St Pierre, Juan F Macias-Velasco, Jessica P Wayhart, Li Yin, Clay F Semenkovich, Heather A Lawson

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 31 citations in OpenAlex.

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  15. Beyond the "Dominant" and "Recessive" Patterns of Inheritance.International journal of molecular sciences · 2024
    Article
  16. Review
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  20. Building Haplotype-Resolved 3D Genome Maps of Chicken Skeletal Muscle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Celine L St PierreDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0001-5465-6601
Juan F Macias-VelascoDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Jessica P WayhartDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Li YinDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Clay F SemenkovichDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Heather A LawsonDepartment of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA.ORCID 0000-0002-3550-5485
Washington University in St. Louis · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
THE WASHU TARGET ENVIRONMENTAL EPIGENOMICS DATA COORDINATION CENTERU24ES026699 · NIEHS · WASHINGTON UNIVERSITY · PI WANG, TING · 2016 to 2021
$5.2M
IDENTIFYING SIGNATURES OF IMPRINTING EFFECTS ASSOCIATED WITH OBESITY AND T2DK01DK095003 · NIDDK · WASHINGTON UNIVERSITY · PI LAWSON, HEATHER A. · 2013 to 2016
$492k
NIDDK NIH HHS K01 DK095003NIDDK NIH HHS P30 DK020579NIEHS NIH HHS U24 ES026699NIGMS NIH HHS T32 GM007067
6 · The paper itself

Abstract

Allele-specific expression (ASE) is a phenomenon in which one allele is preferentially expressed over the other. Genetic and epigenetic factors cause ASE by altering the final composition of a gene's product, leading to expression imbalances that can have functional consequences on phenotypes. Environmental signals also impact allele-specific expression, but how they contribute to this cross talk remains understudied. Here, we explored how genotype, parent-of-origin, tissue, sex, and dietary fat simultaneously influence ASE biases. Male and female mice from a F

Indexed as

Dietary FatsQuantitative Trait LociAllelesAnimalsEpigenesis, GeneticFemaleGene ExpressionMaleMicePolymorphism, Single NucleotideDietary Fats

Identifiers

PMID35501130
PMCPMC9248887
OpenAlexW4225301526

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.