Evidence map›Paper›PMID 35501093›Full record

ArticleBMJ open2022

Imaging features for the prediction of clinical endpoints in chronic liver disease: a scoping review protocol.

Manil D Chouhan, Stuart Andrew Taylor, Anisha Bhagwanani, Charlotte Munday, Mark A Pinnock, Tom Parry, Yipeng Hu, Dean Barratt, Dominic Yu, Rajeshwar P Mookerjee and 2 more

Abstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Manil D ChouhanUCL Centre for Medical Imaging, UCL, London, UK m.chouhan@ucl.ac.uk.ORCID 0000-0001-5903-1002
Stuart Andrew TaylorUCL Centre for Medical Imaging, UCL, London, UK.
Anisha BhagwananiImaging Department, University College London Hospitals NHS Foundation Trust, London, UK.
Charlotte MundayDepartment of Imaging, Royal Free London NHS Foundation Trust, London, UK.
Mark A PinnockUCL Centre for Medical Image Computing, UCL, London, UK.
Tom ParryUCL Centre for Medical Imaging, UCL, London, UK.
Yipeng HuUCL Centre for Medical Image Computing, UCL, London, UK.
Dean BarrattUCL Centre for Medical Image Computing, UCL, London, UK.
Dominic YuDepartment of Imaging, Royal Free London NHS Foundation Trust, London, UK.
Rajeshwar P MookerjeeUCL Institute for Liver and Digestive Health, UCL, London, UK.
Steve HalliganUCL Centre for Medical Imaging, UCL, London, UK.
Sue MallettUCL Centre for Medical Imaging, UCL, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic liver disease is a growing cause of morbidity and mortality in the UK. Acute presentation with advanced disease is common and prioritisation of resources to those at highest risk at earlier disease stages is essential to improving patient outcomes. Existing prognostic tools are of limited accuracy and to date no imaging-based tools are used in clinical practice, despite multiple anatomical imaging features that worsen with disease severity.In this paper, we outline our scoping review protocol that aims to provide an overview of existing prognostic factors and models that link anatomical imaging features with clinical endpoints in chronic liver disease. This will provide a summary of the number, type and methods used by existing imaging feature-based prognostic studies and indicate if there are sufficient studies to justify future systematic reviews. METHODS AND ANALYSIS: The protocol was developed in accordance with existing scoping review guidelines. Searches of MEDLINE and Embase will be conducted using titles, abstracts and Medical Subject Headings restricted to publications after 1980 to ensure imaging method relevance on OvidSP. Initial screening will be undertaken by two independent reviewers. Full-text data extraction will be undertaken by three pretrained reviewers who have participated in a group data extraction session to ensure reviewer consensus and reduce inter-rater variability. Where needed, data extraction queries will be resolved by reviewer team discussion. Reporting of results will be based on grouping of related factors and their cumulative frequencies. Prognostic anatomical imaging features and clinical endpoints will be reported using descriptive statistics to summarise the number of studies, study characteristics and the statistical methods used. ETHICS AND DISSEMINATION: Ethical approval is not required as this study is based on previously published work. Findings will be disseminated by peer-reviewed publication and/or conference presentations.

Indexed as

Liver DiseasesResearch DesignHumansMass ScreeningScoping Reviews as Topiccomputed tomographydiagnostic radiologygastrointestinal imaginghepatologymagnetic resonance imagingultrasound

Identifiers

PMID35501093
PMCPMC9062789

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.