ArticleJournal of the American Society of Nephrology : JASN2022
The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia.
Article in Journal of the American Society of Nephrology : JASN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Association of Malnutrition with Risk of Acute Kidney Injury: A Systematic Review and Meta-Analysis.International journal of clinical practice · 2023Pooled it
- The Role of Bariatric Surgery in Kidney Disease: Evidence, Controversies, and Future Needs.Obesity surgery · 2026Review
- Triglyceride-Glucose Index and Risk of End-Stage Kidney Disease in Young Adults: National Population-Based Cohort Study.JMIR public health and surveillance · 2026Article
- Blood-Brain Barrier Permeability Dynamics and Mediation of Triglyceride-Glucose Index on Acute Ischemic Stroke Outcomes.Journal of the American Heart Association · 2026Article
- Sex-specific mediating role of serum uric acid in the association between dietary diversity and muscle strength in urban community-dwelling older adults.Frontiers in public health · 2026Article
- Association between triglyceride glucose-body mass index and diabetic kidney disease in hospitalized patients with type 2 diabetes mellitus: a retrospective cross-sectional study.Frontiers in medicine · 2026Article
- Association between the C-reactive protein-triglyceride-glucose index (CTI) and the risk of acute kidney injury in critically ill patients with cirrhosis.BMC nephrology · 2025Article
- Predicting depression risk with machine learning models: identifying familial, personal, and dietary determinants.BMC psychiatry · 2025Article
- Obesity and Metabolic Health in CKD.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Preschool age-specific obesity and later-life kidney health: a Mendelian randomization and colocalization study.International journal of obesity (2005) · 2025Article
- Triglyceride glucose index as a biomarker for heart failure risk in H-type hypertension patients.Scientific reports · 2025Article
- Relationship between dietary acid-base load and non-insulin-based resistance measures in patients with chronic kidney disease.Frontiers in endocrinology · 2025Article
- Associations of healthy eating index 2020 and its components with non-alcoholic fatty liver disease in type 2 diabetes patients and the mediating roles of metabolic indicators: NHANES 2007-2018.Frontiers in nutrition · 2025Article
- Association of 24 Conventional and Unconventional Anthropometric Indicators with Pre-Hypertension or Hypertension: A Population-Based Cross-Sectional Study in Chinese Population.Vascular health and risk management · 2025Article
- Clinicopathological Analysis of Patients with Isolated Hematuria and/or Mild Proteinuria.International journal of general medicine · 2025Article
- Association of the Triglyceride-Glucose Index with Body Composition and Laboratory Parameters in Chronic Kidney Disease Stages 3-5.Risk management and healthcare policy · 2025Article
- Relationship of the metabolic score for insulin resistance and the new-onset hypertension: Evidence from CHARLS.PloS one · 2025Article
- Metabolic score and its components are associated with carotid plaque prevalence in young adults.Endocrine · 2024Article
- Comparison of the effects of losartan potassium and benazepril in the treatment of hypertensive patients with insulin resistance.Pakistan journal of medical sciences · 2024Article
- Research progress on bariatric surgery for hyperuricemia.BMC surgery · 2024Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInsulin resistance, hypertension, hyperuricemia, and hypercholesterolemia are hypothesized to be important intermediates in the relationship between excess body weight and CKD risk. However, the magnitude of the total effect of excess body weight on ESKD mediated through these four pathways remains to be quantified.
methodsWe applied a model for analysis of correlated mediators to population-based data from 100,269 Austrian individuals (mean age 46.4 years). Association of body mass index (BMI) was coalesced with ESKD risk into direct association. Indirect associations were mediated through the triglyceride-glucose (TyG) index (as an indicator of insulin resistance), mean arterial pressure (MAP), uric acid (UA), and total cholesterol (TC).
resultsMean follow-up was 23.1 years with 463 (0.5%) incident ESKD cases. An unhealthy metabolic profile (prevalence 32.4%) was associated with a markedly increased ESKD risk (multivariably adjusted hazard ratio (aHR), 3.57; 95% CI, 2.89 to 4.40), independent of BMI. A 5-kg/m
conclusionsTyG index, MAP, and UA, but not TC, mediate the association of BMI with ESKD in middle-aged adults. Our findings highlight that in addition to weight reduction, the control of metabolic risk factors might be essential in mitigating the adverse effects of BMI on kidney function.
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