Evidence map›Paper›PMID 35500862›Full record

ReviewAnnals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2022

Asthma interactions between obesity and other risk factors.

Matthew Wong, Erick Forno, Juan C Celedón

Open access · greenAbstract readReview
In one paragraph

Review in Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Sex, hormones, and lung health.Physiological reviews · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Asthma and Chronic Obstructive Pulmonary Disease.Clinics in chest medicine · 2023
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Matthew WongDivision of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Erick FornoDivision of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Juan C CeledónDivision of Pulmonary Medicine, Department of Pediatrics, University of Pittsburgh, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: juan.celedon@chp.edu.
Children's Hospital of Pittsburgh · US

Funding

Epigenetic Variation and Childhood Asthma in Puerto RicansR01HL117191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2013 to 2020
$5.8M
Nasal epithelial epigenomics and transcriptomics and asthma in Hispanic adultsR01HL152475 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS, ISASI, CARMEN R. · 2021 to 2025
$3.4M
Obesity and Childhood Asthma: The Role of Adipose TissueR01HL149693 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORNO, ERICK · 2020 to 2024
$3.0M
Pittsburgh Training Grant in Pediatric Pulmonary MedicineT32HL129949 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Juan Carlos Celedon · 2016 to 2026
$2.9M
Exposure to violence, epigenetic variation, and asthma in Puerto Rican childrenR01MD011764 · NIMHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CELEDON, JUAN CARLOS · 2017 to 2020
$1.3M
NHLBI NIH HHS R01 HL117191NHLBI NIH HHS R01 HL149693NHLBI NIH HHS R01 HL152475NHLBI NIH HHS T32 HL129949NIMHD NIH HHS R01 MD011764
6 · The paper itself

Abstract

objectiveTo review and critically discuss published evidence on interactions between obesity and selected risk factors on asthma in children and adults, and to discuss potential future directions in this field. DATA SOURCES: National Library of Medicine (via PubMed) STUDY SELECTION: A literature search was conducted for human studies on obesity and selected interactions (with sex, race and ethnicity, socioeconomic status, indoor and outdoor pollutants, depression, anxiety, and diet) on asthma. Studies that were published in English and contained a full text were considered for inclusion in this review.

resultsCurrent evidence supports interactions between obesity and outdoor and indoor air pollutants (including second-hand smoke [SHS]) on enhancing asthma risk, although there are sparse data on the specific pollutants underlying such interactions. Limited evidence also suggests that obesity may modify the effects of depression or anxiety on asthma, whereas little is known about potential interactions between obesity and sex-hormone levels or dietary patterns.

conclusionWell-designed observational prospective studies (eg, for pollutants and sex hormones) and randomized clinical trials (eg, for the treatment of depression) should help establish the impact of modifying coexisting exposures to reduce the harmful effects of obesity on asthma. Such studies should be designed to have a sample size that is large enough to allow adequate testing of interactions between obesity and risk factors that are identified a priori and thus, well characterized, using objective measures and biomarkers (eg, urinary or serum cotinine for SHS, epigenetic marks of specific environmental exposures).

Indexed as

Air PollutantsAsthmaChildHumansObesityProspective StudiesRisk FactorsAir Pollutants

Identifiers

PMID35500862
PMCPMC10825856
OpenAlexW4225146151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.