ArticleJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer2022
A Large-Scale Genome-Wide Gene-Gene Interaction Study of Lung Cancer Susceptibility in Europeans With a Trans-Ethnic Validation in Asians.
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Article in Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
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Authors and funding
51 authors at 20 institutions in 13 countries.
Ruyang ZhangDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, People's Republic of China.
Sipeng ShenDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, People's Republic of China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
Yongyue WeiDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, People's Republic of China.
Ying ZhuDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Yi LiDepartment of Biostatistics, University of Michigan, Ann Arbor, Michigan.
Jiajin ChenDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Jinxing GuanDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Zoucheng PanDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Yuzhuo WangDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
Meng ZhuDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
Junxing XieDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Xiangjun XiaoThe Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Dakai ZhuThe Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Yafang LiThe Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Demetrios AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Stephen LamDepartment of Medicine, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada.
Adonina TardonFaculty of Medicine, University of Oviedo and CIBERESP, Oviedo, Spain.
Chu ChenDepartment of Epidemiology, University of Washington School of Public Health, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Stig E BojesenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Mattias JohanssonSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Angela RischDepartment of Biosciences and Cancer Cluster Salzburg, University of Salzburg, Salzburg, Austria.
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center, Georg August University Göttingen, Göttingen, Germany.
H-Erich WichmannInstitute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University, Munich, Germany.
Gadi RennertClalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Carmel, Haifa, Israel.
Susanne ArnoldMarkey Cancer Center, University of Kentucky, Lexington, Kentucky.
Paul BrennanSection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France.
James D McKaySection of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France.
John K FieldDepartment of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Sanjay S SheteDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Geoffrey LiuPrincess Margaret Cancer Centre, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Angeline S AndrewDepartment of Epidemiology, Department of Community and Family Medicine, Dartmouth Geisel School of Medicine, Hanover, New Hampshire.
Lambertus A KiemeneyDepartment for Health Evidence, Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Shan Zienolddiny-NaruiNational Institute of Occupational Health, Oslo, Norway.
Annelie BehndigDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Mikael JohanssonDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.
Angela CoxDepartment of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, United Kingdom.
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Melinda C AldrichDepartment of Thoracic Surgery and Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Juncheng DaiDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
Hongxia MaDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
Yang ZhaoDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China.
Zhibin HuChina International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, People's Republic of China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Christopher I AmosThe Institute for Clinical and Translational Research, Department of Medicine, Baylor College of Medicine, Houston, Texas.
Hongbing ShenChina International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, People's Republic of China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, People's Republic of China.
Feng ChenDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, People's Republic of China; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, People's Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, People's Republic of China. Electronic address: fengchen@njmu.edu.cn.
David C ChristianiDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, Massachusetts; Pulmonary and Critical Care Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Jiangsu Cancer Hospital · CNNanjing Medical University · CNBaylor College of Medicine · USCentre international de recherche sur le cancer · FRHarvard University · USNational Institutes of Health · USUniversity of Toronto · CABC Cancer Agency · CACarmel Medical Center · ILDartmouth College · USGentofte Hospital · DKMoffitt Cancer Center · USNational Institute of Occupational Health · NORadboud University Nijmegen · NLThe University of Texas MD Anderson Cancer Center · USUmeå University · SEUniversidad de Oviedo · ESUniversity of Göttingen · DEUniversity of Hawaiʻi at Mānoa · USUniversity of Kentucky · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5MTranslational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SUSAN A KORRICK · 1985 to 2026
$44.6MThe Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2MStatistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer ResearchR35CA197449 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI XIHONG LIN · 2015 to 2026
$10.9MMolecular and Genetic Analysis of Lung Cancer SurvivalR01CA092824 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 2002 to 2013
$5.9MInfrastructure Support and Pilot Tissue Collection for the CARET BiorepositoryU01CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI NEUHOUSER, MARIAN L · 2018 to 2022
$2.9MNew Statistical Methods for Modelling Cancer OutcomesR01CA249096 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yi Li · 2021 to 2026
$2.5MCutting Edge Survival Methods for Epidemiological DataR01AG056764 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI NAN, BIN · 2018 to 2021
$1.3MMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA092824NCI NIH HHS R01 CA249096NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA209414NIA NIH HHS R01 AG056764NIEHS NIH HHS P30 ES000002World Health Organization 001
Abstract
introductionAlthough genome-wide association studies have been conducted to investigate genetic variation of lung tumorigenesis, little is known about gene-gene (G × G) interactions that may influence the risk of non-small cell lung cancer (NSCLC).
methodsLeveraging a total of 445,221 European-descent participants from the International Lung Cancer Consortium OncoArray project, Transdisciplinary Research in Cancer of the Lung and UK Biobank, we performed a large-scale genome-wide G × G interaction study on European NSCLC risk by a series of analyses. First, we used BiForce to evaluate and rank more than 58 billion G × G interactions from 340,958 single-nucleotide polymorphisms (SNPs). Then, the top interactions were further tested by demographically adjusted logistic regression models. Finally, we used the selected interactions to build lung cancer screening models of NSCLC, separately, for never and ever smokers.
resultsWith the Bonferroni correction, we identified eight statistically significant pairs of SNPs, which predominantly appeared in the 6p21.32 and 5p15.33 regions (e.g., rs521828
conclusionsImportant G × G interactions were identified and enriched in the 5p15.33 and 6p21.32 regions, which may enhance lung cancer screening models.
Indexed as
Carcinoma, Non-Small-Cell LungLung NeoplasmsCase-Control StudiesEarly Detection of CancerGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideCancer riskGene-gene interactionGenetic screening modelGWASLung cancerSingle nucleotide polymorphism
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