Evidence map›Paper›PMID 35500808›Full record

ArticleNeuroImage2022

Sex-dependent structure of socioemotional salience, executive control, and default mode networks in preschool-aged children with autism.

Brandon A Zielinski, Derek S Andrews, Joshua K Lee, Marjorie Solomon, Sally J Rogers, Brianna Heath, Christine Wu Nordahl, David G Amaral

Abstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Sex and gender in neurodevelopmental conditions.Nature reviews. Neurology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brandon A ZielinskiDepartments of Pediatrics and Neurology, University of Utah School of Medicine, University of Utah, Salt Lake City, UT, USA. Electronic address: brandon.zielinski@hsc.utah.edu.
Derek S AndrewsThe Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California Davis, Sacramento, CA, USA.
Joshua K LeeThe Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California Davis, Sacramento, CA, USA.
Marjorie SolomonThe Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California Davis, Sacramento, CA, USA.
Sally J RogersThe Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California Davis, Sacramento, CA, USA.
Brianna HeathThe Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California Davis, Sacramento, CA, USA.
Christine Wu NordahlThe Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California Davis, Sacramento, CA, USA.
David G AmaralThe Medical Investigation of Neurodevelopmental Disorders (MIND) Institute and Department of Psychiatry and Behavioral Sciences, UC Davis School of Medicine, University of California Davis, Sacramento, CA, USA.

Funding

Specifying and Treating the Anxiety Phenotype in Autism Spectrum DisorderP50HD093079 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NORDAHL, CHRISTINE WU · 2017 to 2021
$11.4M
Interdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8M
Predictors of Cognitive Development in Autism Spectrum DisorderR01MH103284 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SOLOMON, MARJORIE · 2014 to 2024
$6.3M
Neural Phenotypes of Females with Autism Spectrum DisorderR01MH104438 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NORDAHL, CHRISTINE WU · 2014 to 2018
$3.5M
Neurophenotypic Trajectories and Behavioral Outcomes in Autism Spectrum DisorderR01MH103371 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI AMARAL, DAVID G · 2015 to 2019
$3.4M
Brain Network Development in Normal and Autistic ChildrenK08MH100609 · NIMH · UNIVERSITY OF UTAH · PI ZIELINSKI, BRANDON A. · 2014 to 2017
$759k
NICHD NIH HHS P50 HD093079NIMH NIH HHS K08 MH100609NIMH NIH HHS R01 MH103284NIMH NIH HHS R01 MH103371NIMH NIH HHS R01 MH104438NIMH NIH HHS T32 MH073124
6 · The paper itself

Abstract

The structure of large-scale intrinsic connectivity networks is atypical in adolescents diagnosed with autism spectrum disorder (ASD or autism). However, the degree to which alterations occur in younger children, and whether these differences vary by sex, is unknown. We utilized structural magnetic resonance imaging (MRI) data from a sex- and age- matched sample of 122 autistic and 122 typically developing (TD) children (2-4 years old) to investigate differences in underlying network structure in preschool-aged autistic children within three large scale intrinsic connectivity networks implicated in ASD: the Socioemotional Salience, Executive Control, and Default Mode Networks. Utilizing structural covariance MRI (scMRI), we report network-level differences in autistic versus TD children, and further report preliminary findings of sex-dependent differences within network topology.

Indexed as

Autism Spectrum DisorderAutistic DisorderAdolescentBrainBrain MappingChildChild, PreschoolExecutive FunctionHumansMagnetic Resonance ImagingNeural Pathways

Identifiers

PMID35500808
PMCPMC11107798

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.