Evidence map›Paper›PMID 35500657›Full record

ArticleAnalytical biochemistry2022

Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex.

Pravin Pokhrel, Shogo Sasaki, Changpeng Hu, Deepak Karna, Shankar Pandey, Yue Ma, Kazuo Nagasawa, Hanbin Mao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Rational Polyligand Design for G-Quadruplex Multimer Stabilization.Journal of chemical information and modeling · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Pravin PokhrelDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
Shogo SasakiDepartment of Biotechnology and Life Science Faculty of Technology, Tokyo University of Agriculture and Technology (TUAT), 2-14-16 Naka-cho, Koganeishi, Tokyo, 184-8588, Japan.
Changpeng HuDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA; Department of Pharmacy, The Second Affiliated Hospital, Army Medical University, Chongqing, 400037, China.
Deepak KarnaDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
Shankar PandeyDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA.
Yue MaInstitute of Global Innovation Research, Tokyo University of Agriculture and Technology (TUAT), 2-14-16 Naka-cho, Koganeishi, Tokyo, 184-8588, Japan.
Kazuo NagasawaDepartment of Biotechnology and Life Science Faculty of Technology, Tokyo University of Agriculture and Technology (TUAT), 2-14-16 Naka-cho, Koganeishi, Tokyo, 184-8588, Japan. Electronic address: knaga@cc.tuat.ac.jp.
Hanbin MaoDepartment of Chemistry and Biochemistry, Kent State University, Kent, OH, 44242, USA. Electronic address: hmao@kent.edu.
Kent State University · USTokyo University of Agriculture and Technology · JP

Funding

Specific Recognition of G-quadruplexesR01CA236350 · NCI · KENT STATE UNIVERSITY · PI MAO, HANBIN · 2018 to 2022
$1.6M
NCI NIH HHS R01 CA236350
6 · The paper itself

Abstract

Binding between a ligand and a receptor is a fundamental step in many natural or synthetic processes. In biosensing, a tight binding with a small dissociation constant (K

Indexed as

DendrimersG-QuadruplexesTelomeraseHumansLigandsTelomereDendrimersLigandsTelomeraseBindingDendrimer ligandsDisplacement assayG-quadruplexSingle-molecule

Identifiers

PMID35500657
PMCPMC9133229
OpenAlexW4225128287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.