Evidence map›Paper›PMID 35500546›Full record

ReviewNeoplasia (New York, N.Y.)2022

Diet-microbiome interactions in cancer treatment: Opportunities and challenges for precision nutrition in cancer.

K Leigh Greathouse, Madhur Wyatt, Abigail J Johnson, Eugene P Toy, Joetta M Khan, Kelly Dunn, Deborah J Clegg, Sireesha Reddy

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neoplasia (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

K Leigh GreathouseHuman Science and Design, Robbins College of Health and Human Sciences, Baylor University, Waco, TX, USA. Electronic address: leigh_greathouse@baylor.edu.
Madhur WyattHuman Health Performance and Recreation, Robbins College of Health and Human Sciences, Baylor University, Waco, TX, USA.
Abigail J JohnsonDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Eugene P ToyDepartment of Obstetrics and Gynecology, Texas Tech Health Sciences University El Paso (TTUHSC EP), El Paso, TX, USA.
Joetta M KhanNutrition Services Division, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Kelly DunnUniversity of New Mexico Comprehensive Cancer Center, University of New Mexico, Albuquerque, NM, USA.
Deborah J CleggPaul L. Foster School of Medicine, TTUHSC EP, El Paso, TX, USA.
Sireesha ReddyDepartment of Obstetrics and Gynecology, TTUHSC EP, El Paso, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary patterns contribute to cancer risk. Separately, microbial factors influence the development of several cancers. However, the interaction of diet and the microbiome and their joint contribution to cancer treatment response needs more research. The microbiome significantly impacts drug metabolism, immune activation, and response to immunotherapy. One of the critical factors affecting the microbiome structure and function is diet. Data demonstrate that the diet and microbiome composition affects the immune response. Moreover, malnutrition is a significant confounder to cancer therapy response. There is little understanding of the interaction of malnutrition with the microbiome in the context of cancer. This review aims to address the current knowledge of dietary intake patterns and malnutrition among cancer patients and the impact on treatment outcomes. Second, this review will provide evidence linking the microbiome to cancer treatment response and provide evidence of the potentially strong effect that diet could have on this interaction. This review will formulate critical questions that will need further research to understand the diet-microbiome relationship in cancer treatment response and directions for future research to guide us to precision nutrition therapy to improve cancer outcomes.

Indexed as

Gastrointestinal MicrobiomeMalnutritionMicrobiotaNeoplasmsDietHumansNutritional StatusCachexiaDietary intakeDietary risk factorsMalnutritionOncologyQuality of life

Identifiers

PMID35500546
PMCPMC9065883

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.