ArticleJournal of clinical laboratory analysis2022
The relation of common inflammatory cytokines with anxiety and depression and their values in estimating cardiovascular outcomes in coronary heart disease patients.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Meta-analysis of the association between interleukin-17 and ischemic cardiovascular disease.BMC cardiovascular disorders · 2024Pooled it
- Anxiety is associated with systemic pro-inflammatory profile and plasma lipid changes in Mexican young adults.Frontiers in cellular neuroscience · 2026Article
- Anxiety disorders following percutaneous coronary intervention for acute myocardial infarction: A comprehensive review of clinical manifestations and interventions.World journal of psychiatry · 2025Review
- The Bidirectional Relationship Between Myocardial Infarction and Depression: Risk Factors, Mechanisms, and Interventions.Biomedicines · 2025Review
- Depressive state on cardiac remodeling and left ventricular function in chronic heart failure: A retrospective study.World journal of psychiatry · 2025Article
- Knowledge Domain and Emerging Trends in Heart Failure and Anxiety Comorbidity: A Scientometric Analysis.Journal of multidisciplinary healthcare · 2025Article
- Pathophysiological dynamics of acute myocardial infarction rats under chronic psychological stress at different time points.Scientific reports · 2024Article
- Association of interleukin-2 and interleukin-10 with the pathophysiology and development of generalized anxiety disorder: a case-control study.BMC psychiatry · 2024Article
- Depression Following Acute Coronary Syndrome: A Review.Reviews in cardiovascular medicine · 2023Review
- Longitudinal change of six common inflammatory cytokines and their relationship to anxiety, depression, and cognitive impairment in acute ischemic stroke patients.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- Interrelations between clinical-psychological features and bone mineral density changes in post-menopausal women undergoing anti-osteoporotic treatment: a two-year follow-up.Frontiers in endocrinology · 2023Article
- Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms.Neuropsychiatric disease and treatment · 2023Article
- The relation of common inflammatory cytokines with anxiety and depression and their values in estimating cardiovascular outcomes in coronary heart disease patients.Journal of clinical laboratory analysis · 2022Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory cytokines are associated with the occurrence and severity of psychological disorders in cerebro-cardiovascular disease patients. This study aimed to investigate the correlation of inflammatory cytokines with anxiety and depression in coronary heart disease (CHD) patients and their values for estimating cardiovascular outcomes.
methodsTotally, 150 CHD patients and 50 healthy subjects were enrolled. Then, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, IL-10, and IL-17 in their serum samples were detected using ELISA assay; anxiety and depression were assessed by the HADS score. For CHD patients, major adverse cardiac events (MACE) were recorded and evaluated.
resultsCHD patients presented with increased TNF-α (median: 50.0 vs. 37.0 pg/ml, p < 0.001), IL-1β (median: 2.7 vs. 2.0 pg/ml, p < 0.001), IL-6 (median: 24.7 vs. 24.3 pg/ml, p = 0.032), IL-17A (median: 58.6 vs. 43.6 pg/ml, p < 0.001), HADS-A score (p < 0.001), HADS-D score (p < 0.001), anxiety rate (p < 0.001), and depression rate (p < 0.001) compared to healthy subjects. Then, TNF-α (p = 0.003), IL-1β (p = 0.023), and IL-17A (p < 0.001) were related to elevated HADS-A score. Also, TNF-α (p = 0.014) and IL-17A (p = 0.020) positively, while IL-10 (p = 0.047) negatively related to the HADS-D score in CHD patients. Interestingly, elevated TNF-α and IL-17A were associated with anxiety and depression occurrence in CHD patients (all p < 0.05). Inspiringly, only TNF-α high, but not other cytokines, was related to elevated accumulating MACE (p = 0.041), while no correlation of anxiety (p = 0.173) or depression (p = 0.068) with accumulating MACE was observed.
conclusionTNF-α and IL-17A correlate with anxiety and depression, while only TNF-α high is related to elevated accumulating MACE in CHD patients.
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