Evidence map›Paper›PMID 35499813›Full record

ArticleInternational journal of behavioral medicine2023

Life Instability Associated with Lower ART Adherence and Other Poor HIV-Related Care Outcomes in Older Adults with HIV.

Elliott R Weinstein, Audrey Harkness, Gail Ironson, Cho-Hee Shrader, Dustin T Duncan, Steven A Safren

Open access · greenAbstract read
In one paragraph

Article in International journal of behavioral medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elliott R WeinsteinDepartment of Psychology, University of Miami, 1120 NW 14th StreetSuite 787, Miami, FL, 33136, USA. erw73@miami.edu.ORCID http://orcid.org/0000-0002-5085-7470
Audrey HarknessDepartment of Public Health Sciences, University of Miami, Miami, FL, USA.ORCID http://orcid.org/0000-0003-2290-9904
Gail IronsonDepartment of Psychology, University of Miami, 1120 NW 14th StreetSuite 787, Miami, FL, 33136, USA.ORCID http://orcid.org/0000-0003-4770-1464
Cho-Hee ShraderDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.ORCID http://orcid.org/0000-0003-3500-8507
Dustin T DuncanDepartment of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, USA.ORCID http://orcid.org/0000-0001-8586-8711
Steven A SafrenDepartment of Psychology, University of Miami, 1120 NW 14th StreetSuite 787, Miami, FL, 33136, USA.ORCID http://orcid.org/0000-0002-0121-0806
University of Miami · USColumbia University · US

Funding

University of Miami Developmental Center for AIDS Research (D-CFAR)P30AI073961 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Rana Chakraborty · 2007 to 2026
$33.8M
The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)Research Core & MHD-CEP30MH133399 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI Audrey Harkness · 2023 to 2026
$8.9M
University of Miami Developmental HIV/AIDS Mental Health Research Center (D-ARC)P30MH116867 · NIMH · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2019 to 2023
$6.5M
Developing and Pilot Testing Peer Ambassador Stories for Increasing HIV-Prevention and Behavioral Health Treatment Uptake among Latino MSMK23MD015690 · NIMHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI HARKNESS, AUDREY · 2020 to 2025
$1.1M
Addressing psychosocial comorbidities in HIV treatment and preventionK24DA040489 · NIDA · UNIVERSITY OF MIAMI CORAL GABLES · PI SAFREN, STEVEN A · 2016 to 2020
$931k
Latinx MSM PrEP Disparities due to Immigration Stress and Drug Use NetworksF31MD015988 · NIMHD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHRADER, CHO-HEE · 2020 to 2020
$46k
NIAID NIH HHS P30 AI073961NIDA NIH HHS K24 DA040489NIMHD NIH HHS F31 MD015988NIMHD NIH HHS K23 MD015690NIMH NIH HHS P30 MH116867NIMH NIH HHS P30 MH133399
6 · The paper itself

Abstract

backgroundLife instability may be an important factor for HIV-related care outcomes in older adults living with HIV (OALWH). This study examined the degree to which an 11-item life instability index (LII) composed of individual- and community-level indicators was associated with HIV-related care outcomes-viral load, antiretroviral (ART) medication adherence, rates of detectable viral load, and HIV care appointment non-adherence among OALWH in the Miami area.

methodsSix hundred twenty-three OALWH completed an interviewer-administered assessment (English or Spanish), which was matched with medical record data.

resultsParticipants reported about six LII indicators each (M = 6.08, SD = 1.44). Greater index scores were associated with worse self-reported ART adherence (b =  - 1.14, p = 0.03), lower observed appointment adherence (b = 0.02, p < 0.01), higher viral load (b = 0.09, p = 0.02), and greater odds of viral detection (OR = 1.22, p = 0.01). Regarding health behaviors, life instability was significantly associated with increased illicit substance use among participants and not associated with depression or anxiety. The association of life instability to ART adherence remained significant (although attenuated) when controlling for the significant effects of substance use (b =  - 0.40, BSTP [- 0.87, - 0.09]).

conclusionThis present study is the first to examine an additive life instability index and its association with HIV-related behavioral and biomedical health outcomes among a population of OALWH. Greater indicators of life instability among OALWH may lead to poorer HIV-related health outcomes above and beyond the net of the effects of depression, anxiety, and substance use.

Indexed as

HIV InfectionsSubstance-Related DisordersAgedAnti-Retroviral AgentsAnxietyHumansMedication AdherenceSelf ReportViral LoadAnti-Retroviral AgentsBehavioral medicineHealth disparitiesHIV/AIDSLife instabilityOlder adults

Identifiers

PMID35499813
PMCPMC9626397
OpenAlexW4225278640

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.