ArticleHeart and vessels2022
Incidence and prognostic impact of the calcified nodule in coronary artery disease patients with end-stage renal disease on dialysis.
Article in Heart and vessels, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Calcified nodule as a distinct morphological risk factor after intravascular ultrasound-guided percutaneous coronary intervention.Heart and vessels · 2026Article
- The Weston Score in coronary artery calcification among patients with End-Stage Renal Disease.Journal of cardiothoracic surgery · 2026Article
- Review
- Prognostic Role and Therapeutic Implications of Intravascular Optical Coherence Tomography Detected Coronary Plaque Microstructures in Patients with Coronary Artery Disease.Journal of clinical medicine · 2025Review
- Optical coherence tomography findings after drug-coated balloon treatment forFrontiers in cardiovascular medicine · 2025Article
- Characteristics of calcified nodule attributable to culprit lesion in acute coronary syndrome: A systematic review and meta-analysis.iScience · 2024Article
- Measuring gait parameters from a single chest-worn accelerometer in healthy individuals: a validation study.Scientific reports · 2024Article
- Renal Dysfunction Increases Risk of Adverse Cardiovascular Events in 5-Year Follow-Up Study of Intermediate Coronary Artery Lesions.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Serial longitudinal changes of coronary calcified plaques with clear outer borders under intensive lipid management: insights from optical coherence tomography.Heart and vessels · 2024Article
- Clinical Outcomes and Unique Restenosis of Calcified Nodule in Heavily Calcified Coronary Artery.Journal of atherosclerosis and thrombosis · 2023Article
- Mean annual intradialytic blood pressure decline and cardiovascular events in Japanese patients on maintenance hemodialysis.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Comparison of revascularization with conservative medical treatment in maintenance dialysis patient with coronary artery disease: a systemic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary artery calcification is frequently observed in coronary artery disease (CAD) patients with end-stage renal disease (ESRD). Calcified nodule (CN) is recognized as one of the vulnerable plaque characteristics responsible for acute coronary syndrome (ACS). Although CN is a cause of ACS in only 10%, its prevalence may be higher in elderly patients and/or ESRD. The aim of this study is to investigate incidence, clinical characteristics, and prognostic impact of CN in CAD patients with ESRD on dialysis. A total of 51 vessels from 49 CAD patients with ESRD on dialysis were enrolled in this study. CN was defined as a high-backscattering mass protruding into the lumen with a strong signal attenuation and an irregular surface by optical coherence tomography. Incidence, clinical characteristics and prognosis of patients with CN were studied. Major adverse cardiac events (MACE) were defined as a composite of all-cause death, non-fatal myocardial infarction, target vessel revascularization (TVR) and stroke. CNs were observed in 30 vessels from 29 patients (59.2%). Duration of dialysis was significantly longer in CN group than in non-CN group (P = 0.03). Overall, all-cause death, cardiac death, TVR and MACE occurred in 7 (14.3%), 3 (6.1%), 11 (22.4%) and 16 (32.7%) patients during follow-up (median 826 days), respectively. Kaplan-Meier survival analysis revealed that MACE-free survival was significantly lower in patients with CN compared with those without CN (Log-rank, P = 0.036).In conclusion, CN was observed in about 60% of the CAD patients with ESRD and was associated with duration of dialysis and worse prognosis.
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