Evidence map›Paper›PMID 35499622›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2022

Utility and limitations of metabolic parameters in head and neck cancer: finding a practical segmentation method.

Jefferson Rijo-Cedeño, Jorge Mucientes, Ithzel María Villarreal, Ana Royuela, Patricia García Vicente, José Ramón García-Berrocal

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jefferson Rijo-CedeñoDepartment of Otorhinolaryngology-Head and Neck Surgery, Puerta de Hierro University Hospital, Majadahonda, Spain. jefferson.rijo@estudiante.uam.es.ORCID http://orcid.org/0000-0001-6313-7061
Jorge MucientesDepartment of Nuclear Medicine, Puerta de Hierro University Hospital, Majadahonda, Spain.ORCID http://orcid.org/0000-0002-3107-5326
Ithzel María VillarrealDepartment of Otorhinolaryngology-Head and Neck Surgery, Fuenlabrada University Hospital, Fuenlabrada, Spain.ORCID http://orcid.org/0000-0003-2902-5386
Ana RoyuelaBiostatistics Unit, Biomedical Research Institute IDIPHISA, CIBERESP, Majadahonda, Spain.
Patricia García VicenteDepartment of Otorhinolaryngology-Head and Neck Surgery, Puerta de Hierro University Hospital, Majadahonda, Spain.
José Ramón García-BerrocalDepartment of Otorhinolaryngology-Head and Neck Surgery, Puerta de Hierro University Hospital, Majadahonda, Spain.ORCID http://orcid.org/0000-0003-2747-2991
Hospital Universitario Puerta de Hierro Majadahonda · ESHospital Universitario de Fuenlabrada · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough metabolic tumor volume (MTV) and total lesion glycolysis (TLG) have shown good prognostic value in head and neck cancer (HNC), there are still many issues to resolve before their potential application in standard clinical practice. The purpose of this study was to compare the discrimination ability of two relevant segmentation methods in HNC and to evaluate the potential benefit of adding lymph nodes' metabolism (LNM) to the measurements.

methodsWe retrospectively analyzed a recently published database of 62 patients with HNC treated with chemoradiotherapy. MTV and TLG were measured using an absolute threshold of SUV2.5. Comparison analysis with previously published background-level threshold (BLT) results was done through Concordance index (C-index) in eight prognostic models.

resultsBLT obtained better C-index values in five out of the eight models. The addition of LNM improved C-index values in six of the prognostic models.

conclusionWe found a potential benefit in adding LNM to the main tumor measurements, as well as in using a BLT for MTV segmentation compared to the most commonly used SUV2.5 threshold. Despite its limitations, this study suggests a practical and simple manner to use these parameters in standard clinical practice, aiming to help elaborate a general consensus.

Indexed as

Fluorodeoxyglucose F18Head and Neck NeoplasmsChemoradiotherapyHumansPositron-Emission TomographyPositron Emission Tomography Computed TomographyPrognosisRadiopharmaceuticalsRetrospective StudiesTumor BurdenFluorodeoxyglucose F18RadiopharmaceuticalsCancerHead and neckMTVPETTLG

Identifiers

PMID35499622
PMCPMC9363397
OpenAlexW4225276520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.