Evidence map›Paper›PMID 35499059›Full record

ReviewJournal of advanced research2022

Extracellular vesicles-mediated interaction within intestinal microenvironment in inflammatory bowel disease.

Qichen Shen, Zhuizui Huang, Jiachen Yao, Yuanxiang Jin

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.

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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Qichen ShenDepartment of Biotechnology, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Zhuizui HuangDepartment of Biotechnology, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Jiachen YaoFaculty of Technology, University of Turku, Turku 20014, Finland.
Yuanxiang JinDepartment of Biotechnology, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
Zhejiang University of Technology · CNUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The intestinal tract is a complicated ecosystem with dynamic homeostasis via interaction of intestine and microbiota. Inflammatory bowel disease (IBD) is chronic intestinal inflammation involving dysbiosis of intestinal microenvironment. Extracellular vesicles (EVs), as vital characteristics of cell-cell and cell-organism communication, contribute to homeostasis in intestine. Recently, EVs showed excellent potential for clinical applications in disease diagnoses and therapies. Aim of Review: Our current review discusses the modulatory functions of EVs derived from different sources in intestine, especially their effects and applications in IBD clinical therapy. EV-mediated interaction systems between host intestine and microbiota were established to describe possible mechanisms of IBD pathogenesis and its cure. Key Scientific Concepts of Review: EVs are excellent vehicles for delivering molecules containing genetic information to recipient cells. Multiple pieces of evidence have illustrated that EVs participate the interaction between host and microbiota in intestinal microenvironment. In inflammatory intestine with dysbiosis of microbiota, EVs as regulators target promoting immune response and microbial reconstruction. EVs-based immunotherapy could be a promising therapeutic approach for the treatment of IBD in the near future.

Indexed as

Extracellular VesiclesInflammatory Bowel DiseasesMicrobiotaDysbiosisHumansIntestinesANXA1, Annexin A1BMSC, bone marrow mesenchymal stem cellCD, Crohn’s diseaseCMVs, Cytoplasmic membrane vesiclesCRC, Colorectal cancerDSS, Dextran sulfate sodiumE-cadherin, Epithelial cadherin. EMT, Epithelial-mesenchymal transitionECN, E. coli strain Nissle 1917E. coli, Escherichia coliEVs, Extracellular vesiclesExtracellular vesiclesFMT, Fecal microbiota transplantationGI, GastrointestinalhucMSC, Human umbilical cord MSCIBD, Inflammatory bowel diseaseIECs, Intestinal epithelial cellsInflammatory bowel diseaseIntestinal barrierLPS, lipopolysaccharideMicrobiotaMSC, Marrow-derived mesenchymal stromal cellsMVs, Membrane vesiclesNEAT1, Nuclear paraspeckle assembly transcript 1OMVs, Outer-membrane vesiclesPSMA7, proteasome subunit alpha type 7SCFA, Short-chain fatty acidTherapyTJs, tight junctionsTLR, Toll-like receptorTNBS, 2,4,6-trinitrobenzenesulfonic acidTreg, Regulatory T cellUC, Ulcerative colitis

Identifiers

PMID35499059
PMCPMC9039646
OpenAlexW3180459665

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.