Evidence map›Paper›PMID 35499052›Full record

ArticleJournal of advanced research2022

Hypoxia inducible lncRNA-CBSLR modulates ferroptosis through m6A-YTHDF2-dependent modulation of CBS in gastric cancer.

Hui Yang, Yiren Hu, Mingzhe Weng, Xiaocen Liu, Ping Wan, Ye Hu, Mingzhe Ma, Yan Zhang, Hongping Xia, Kun Lv

Open access · goldAbstract read
In one paragraph

Article in Journal of advanced research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 177 papers.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 238 citations in OpenAlex.

  1. Review
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  11. RNA modifications and cancer ferroptosis.Cancer cell international · 2026
    Review
  12. Article
  13. Article
  14. Article
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  16. Review
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  19. mFrontiers in cell and developmental biology · 2026
    Review
  20. Review

117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Hui YangKey Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution (Wannan Medical College), Wuhu, Anhui 241001, China.
Yiren HuKey Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution (Wannan Medical College), Wuhu, Anhui 241001, China.
Mingzhe WengKey Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution (Wannan Medical College), Wuhu, Anhui 241001, China.
Xiaocen LiuKey Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution (Wannan Medical College), Wuhu, Anhui 241001, China.
Ping WanKey Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution (Wannan Medical College), Wuhu, Anhui 241001, China.
Ye HuState Key Laboratory for Oncogenes and Related Genes; Division of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Mingzhe MaKey Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution (Wannan Medical College), Wuhu, Anhui 241001, China.
Yan ZhangKey Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution (Wannan Medical College), Wuhu, Anhui 241001, China.
Hongping XiaLaboratory of Cancer Genomics, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore.
Kun LvKey Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution (Wannan Medical College), Wuhu, Anhui 241001, China.
First Affiliated Hospital of Wannan Medical College · CNWannan Medical College · CNState Key Laboratory of Oncogene and Related Genes · CNNational Cancer Centre Singapore · SGXinHua Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Tumors are usually refractory to anti-cancer therapeutics under hypoxic conditions. However, the underlying molecular mechanism remains to be elucidated. Objectives: Our study intended to identify hypoxia inducible lncRNAs and their biological function in gastric cancer (GC). Methods: Differentially expressed lncRNAs were determined by microarray analysis between GC cells exposed to hypoxia (1% O Results: We identified a hypoxia-induced lncRNA- Conclusion: Our study reveals a novel mechanism in how HIF1α/

Indexed as

FerroptosisRNA, Long NoncodingStomach NeoplasmsHumansHypoxiaRNA-Binding ProteinsRNA, MessengerTranscription FactorsRNA-Binding ProteinsRNA, Long NoncodingRNA, MessengerTranscription FactorsYTHDF2 protein, human4-HNE, 4-hydroxynonenalAJCC, American Joint Committee on CancerCDS, coding sequenceChemoresistanceCHIP, chromatin immunoprecipitationDZNeP, 3-deazaneplanocin AFBS, fetal bovine serumFerroptosisGastric cancerGC, gastric cancerGEO, Gene Expression OmnibusHE, Hematoxylin and eosinHREs, hypoxia response elementsHypoxiaIHC, immunohistochemicallncRNAlncRNA, long noncoding RNAMDA, malondialdehydeqPCR, quantitative real-time PCRRIP, RNA immunoprecipitationTCGA, the cancer genome atlasTNM, tumor-node-metastasis staging systemYTHDF2, YTH domain family protein 2

Identifiers

PMID35499052
PMCPMC9039740
OpenAlexW4229043487

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.