Evidence map›Paper›PMID 35498984›Full record

ArticleFood chemistry: X2022

Neuroprotective potential of terpenoid-rich extracts from orange juice by-products obtained by pressurized liquid extraction.

José David Sánchez-Martínez, Gerardo Alvarez-Rivera, Rocio Gallego, Mariane Bittencourt Fagundes, Alberto Valdés, Jose A Mendiola, Elena Ibañez, Alejandro Cifuentes

Open access · goldAbstract read
In one paragraph

Article in Food chemistry: X, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Dichloromethane Extract fromAntioxidants (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. International journal of molecular sciences · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Secondary Terpenes inBiomedicines · 2022
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

José David Sánchez-MartínezLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.
Gerardo Alvarez-RiveraLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.
Rocio GallegoLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.
Mariane Bittencourt FagundesDepartment of Food Technology and Science, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.
Alberto ValdésLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.
Jose A MendiolaLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.
Elena IbañezLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.
Alejandro CifuentesLaboratory of Foodomics, Institute of Food Science Research, CIAL, UAM-CSIC, Nicolás Cabrera 9, 28049 Madrid, Spain.
Instituto de Investigación en Ciencias de la Alimentación · ESUniversidade Federal de Santa Maria · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pressurized liquid extraction (PLE) conditions were optimized to improve the recovery of orange (Citrus sinensis) by-products terpenoids. The neuroprotective potential of the PLE extracts were tested against a set of in-vitro assay (antioxidant (ABTS), reactive oxygen/nitrogen species (ROS/RNS)) as well as enzymatic tests (acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and lipoxygenase (LOX)). Gas chromatography coupled to high-resolution mass spectrometry (GC-q-TOF-MS) analysis revealed a higher enrichment in mono- and sesquiterpenoids of the PLE extracts with the highest neuroprotection capacity.

Indexed as

Anti-inflammatoryGC-q-TOF-MSGreen-extractionNeuroprotectiveOrange juice by-productsPressurized liquid extractionTerpenoids

Identifiers

PMID35498984
PMCPMC9040013
OpenAlexW4210495003

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.