Evidence map›Paper›PMID 35498896›Full record

ArticleClinical kidney journal2022

Blood pressure targets in CKD 2021: the never-ending guidelines debacle.

Sol Carriazo, Pantelis Sarafidis, Charles J Ferro, Alberto Ortiz

Open access · goldAbstract readEditorial
In one paragraph

Article in Clinical kidney journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Mortality according to ambulatory blood pressure in hypertensive patients with normal or impaired kidney function.Hypertension research : official journal of the Japanese Society of Hypertension · 2025
    Article
  4. Brazilian Guidelines of Hypertension - 2025.Arquivos brasileiros de cardiologia · 2025
    Article
  5. Very low SBP targets and the boom-and-bust cycle of benefit and adverse kidney events.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Ageing meets kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  12. Ageing meets kidney disease.Clinical kidney journal · 2022
    Article
  13. Hypertension in kidney transplant recipients.World journal of transplantation · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Sol CarriazoDepartment of Medicine, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0002-6697-5279
Pantelis SarafidisDepartment of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloníki, Greece.ORCID https://orcid.org/0000-0002-9174-4018
Charles J FerroDepartment of Renal Medicine, University Hospitals Birmingham, Birmingham, UK.ORCID https://orcid.org/0000-0003-0577-7081
Alberto OrtizDepartment of Medicine, School of Medicine, Universidad Autonoma de Madrid, Madrid, Spain.ORCID https://orcid.org/0000-0002-9805-9523
Hospital Universitario Fundación Jiménez Díaz · ESAristotle University of Thessaloniki · GRNIHR Surgical Reconstruction and Microbiology Research Centre · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In 2021, two updated clinical guidelines were published, providing guidance on blood pressure (BP) targets for people with chronic kidney disease (CKD). Kidney Disease: Improving Global Outcomes (KDIGO) updated its 2012 Clinical Practice Guideline for the Management of BP in CKD. Different systolic blood pressure (SBP) and diastolic blood pressure (DBP) targets for CKD (<130/80 and <140/90 mmHg, respectively, for people with a urinary albumin: creatinine ratio >30 mg/g or without pathological albuminuria) were replaced by a single number: an SBP target of <120 mmHg is suggested, when tolerated. This represents a major decrease in the SBP target and the abandonment of DBP targets. The European Society of Cardiology (ESC) also published a 2021 Clinical Guideline on Cardiovascular Disease Prevention in Clinical Practice that updates a prior 2016 guideline on prevention and the 2018 ESC/European Society of Hypertension Clinical Practice Guidelines for the Management of Arterial Hypertension. The 2021 ESC guideline was endorsed by 12 European scientific societies. The recommended office BP targets for people with CKD are <140-130 mmHg SBP (lower SBP is acceptable if tolerated) and <80 mmHg DBP. The question is: What should the practicing physician do now: treat hypertension in people with CKD to an SBP target of <120 mmHg or to a target of <140-130 mmHg? Major guideline bodies are aware of the activities of other major players. There is an urgent need for guideline bodies to establish communication channels, search consensus on major issues that impact the health of hundreds of millions of people worldwide and end individualism in guidelines generation.

Indexed as

blood pressure targetschronic kidney diseaseEuropean Society of Cardiologyguidelineshypertension

Identifiers

PMID35498896
PMCPMC9050556
OpenAlexW4210916015

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.