Evidence map›Paper›PMID 35498434›Full record

ArticleFrontiers in endocrinology2022

Case Report: Giant Paraganglioma of the Skull Base With Two Somatic Mutations in

Ailsa Maria Main, Götz Benndorf, Ulla Feldt-Rasmussen, Kåre Fugleholm, Thomas Kistorp, Anand C Loya, Lars Poulsgaard, Åse Krogh Rasmussen, Maria Rossing, Christine Sølling and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Ailsa Maria MainDepartment of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Götz BenndorfDepartment of Radiology, Copenhagen University Hospital, Copenhagen, Denmark.
Ulla Feldt-RasmussenDepartment of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Kåre FugleholmDepartment of Neurosurgery, Copenhagen University Hospital, Copenhagen, Denmark.
Thomas KistorpDepartment of Anaesthesiology, Copenhagen University, Copenhagen, Denmark.
Anand C LoyaFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Lars PoulsgaardDepartment of Neurosurgery, Copenhagen University Hospital, Copenhagen, Denmark.
Åse Krogh RasmussenDepartment of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Maria RossingCenter for Genomic Medicine, Rigshospitalet, Copenhagen, Denmark.
Christine SøllingDepartment of Neuroanaesthesiology, Copenhagen University Hospital, Copenhagen, Denmark.
Marianne Christina KloseDepartment of Medical Endocrinology and Metabolism, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Copenhagen University Hospital · DKRigshospitalet · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Head and neck paragangliomas (HNPGLs) are neuroendocrine tumors. They arise from the parasympathetic ganglia and can be either sporadic or due to hereditary syndromes (up to 40%). Most HNPGLs do not produce significant amounts of catecholamines. We report a case of a giant paraganglioma of the skull base with an unusually severe presentation secondary to excessive release of norepinephrine, with a good outcome considering the severity of disease. A 39-year-old Caucasian woman with no prior medical history was found unconscious and emaciated in her home. In the intensive care unit (ICU) the patient was treated for multi-organ failure with multiple complications and difficulties in stabilizing her blood pressure with values up to 246/146 mmHg. She was hospitalized in the ICU for 72 days and on the 31

Indexed as

LabetalolParagangliomaAdultFemaleHumansMutationNormetanephrinePTEN PhosphohydrolaseSkull BaseSuccinate DehydrogenaseLabetalolNormetanephrinePTEN PhosphohydrolasePTEN protein, humanSDHB protein, humanSuccinate Dehydrogenasealpha blockadecatecholamineHead and neck paraganglioma (HNPGL)multidisciplinary approachneuroendochrine tumorparagangliogliomarehabilitationSDHB gene

Identifiers

PMID35498434
PMCPMC9044027
OpenAlexW4223978313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.