Evidence map›Paper›PMID 35498424›Full record

ArticleFrontiers in endocrinology2022

Effect of Blastocyst Morphology and Developmental Rate on Euploidy and Live Birth Rates in Preimplantation Genetic Testing for Aneuploidy Cycles With Single-Embryo Transfer.

Na Li, Yichun Guan, Bingnan Ren, Yuchao Zhang, Yulin Du, Hongjiao Kong, Yongjie Zhang, Hua Lou

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06165367 (Impact of Hyaluronan-enriched Medium on Pregnancy Outcomes Following Euploid Blastocyst Transfers), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06165367 narecruitingnot on this mapstarted 2024, after this paper: background citation

Impact of Hyaluronan-enriched Medium on Pregnancy Outcomes Following Euploid Blastocyst Transfers

TypeinterventionalSponsorART Fertility Clinics LLCRan2024 to 2026Enrolled783ConditionsInfertility, Implantation Rate, Clinical Pregnancy Rate, Live Birth RateArmsEmbryoGlue Medium
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  16. Incidence of aneuploidy in embryos studied using PGT-A in Mexico: a clinical retrospective experience.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
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  19. Preimplantation genetic testing for aneuploidy: predictive embryonic factors.Journal of assisted reproduction and genetics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Na LiReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yichun GuanReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Bingnan RenReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuchao ZhangReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yulin DuReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hongjiao KongReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yongjie ZhangReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hua LouReproductive Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Third Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aim of this study was to investigate whether blastocyst morphology and developmental rate are associated with euploidy and live birth rates (LBRs) in single euploid frozen-thawed embryo transfer (FET) cycles. Design: Retrospective cohort study. Methods: This study included 431 preimplantation genetic testing for aneuploidy (PGT-A) cycles followed by 393 FET cycles performed at our center from June 2017 to March 2021. All cycles were analyzed for euploidy based on blastocyst morphology (good, average and poor), developmental stage (day 5 and 6) and maternal age (< 35 and ≥ 35 years old). Multivariate logistic analysis models were used to identify the independent effects of conventional blastocyst morphology, developmental rate and morphological parameters (degree of blastocoele expansion, and grade of inner cell mass and trophectoderm (TE)) on LBRs. Results: In the group of women aged < 35 years, compared with poor-quality blastocysts, good-quality blastocysts (62.90% vs. 32.46%; odds ratio (OR) 3.163, 95% confidence interval (CI) 2.247-4.451; Conclusion: Poor-quality embryos have reduced rates of euploidy. However, blastocyst developmental rate only significantly associates with euploidy rates in women aged younger than 35. Furthermore, only TE grade and blastocyst developmental rate are significantly associated with LBRs following FET cycles.

Indexed as

AneuploidyBirth RateAdultBlastocystEmbryo TransferFemaleGenetic TestingHumansRetrospective Studiesblastocyst morphologydevelopmental rateeuploid rateslive birth ratespreimplantation genetic testing for aneuploidy

Identifiers

PMID35498424
PMCPMC9044033
OpenAlexW4224098972

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.