Evidence map›Paper›PMID 35498388›Full record

ReviewJournal of oral biology and craniofacial research

Depleting levels of endogenous anti-oxidant superoxide dismutase in oral sub-mucous fibrosis: A systematic review and meta-analysis.

Khadijah Mohideen, C Krithika, Nadeem Jeddy, Shaheen Shamsuddin, Sulphi Abdul Basheer, Shan Sainudeen, Asma Ahmed Alomar, Samirah Ahmed Sahly, Shazia Mushtaq, A Thirumal Raj and 3 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 3 countries.

Khadijah MohideenDepartment of Oral Pathology and Microbiology, Sathyabama Dental College and Hospital, Sathyabama Institute of Science and Technology, Chennai, India.
C KrithikaMeenakshi Academy of Higher Education and Research, Chennai, India.
Nadeem JeddyDepartment of Oral Pathology and Microbiology, Thai Moogambigai Dental College and Hospital, Dr. M.G.R. Educational and Research Institute, Chennai, India.
Shaheen ShamsuddinDepartment of Orthodontics, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Sulphi Abdul BasheerDepartment of Oral and Maxillofacial Surgery, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Shan SainudeenDepartment of Restorative Dentistry, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
Asma Ahmed AlomarCollege of Dentistry, Jazan University, Jazan, Saudi Arabia.
Samirah Ahmed SahlyCollege of Dentistry, Jazan University, Jazan, Saudi Arabia.
Shazia MushtaqCollege of Applied Medical Sciences, Dental Health Department, King Saud University, Riyadh, Saudi Arabia.
A Thirumal RajDepartment of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India.
Alessio ZanzaDepartment of Maxillo and Oro-Facial Sciences, University of Rome La Sapienza, Rome, Italy.
Luca TestarelliDepartment of Maxillo and Oro-Facial Sciences, University of Rome La Sapienza, Rome, Italy.
Shankargouda PatilDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry Jazan University, Jazan, Saudi Arabia.
Jazan University · SAKing Khalid University · SASapienza University of Rome · ITDr. M.G.R. Educational and Research Institute · INKing Saud University · SAMeenakshi Academy of Higher Education and Research · INSathyabama Institute of Science and Technology · INSri Venkateswara Medical College and Ruia Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The systematic review is aimed to assess the antioxidant status by superoxide dismutase level in oral sub-mucous fibrosis using available literature. Materials and methods: A literature search was accomplished electronically in Pubmed (MeSH), Science Direct, Scopus, Web of Science core collection, Cochrane, and Cross-reference, using the keywords such as 'oral submucous fibrosis,' 'antioxidant status' and 'superoxide dismutase.' Results: Of the 352 articles identified, only 16 satisfied the selection criteria and were included in the systematic review. Among the selected, six studies were included for serum level analysis of superoxide dismutase. The assessment showed a significant reduction of serum superoxide dismutase in oral submucous fibrosis patients than in control (p < 0.004). The mean difference in serum superoxide dismutase concentration between oral submucous fibrosis and healthy subjects was -86.23 U/ml (95% CI -145.30, -27.17). The serum SOD level was significantly reduced as the disease progressed to stage I or stage II (p < 0.001) compared to the control group. Conclusion: The studies showed significantly lower levels of superoxide dismutase in various human samples of patients with OSMF. Therefore, further studies are required to estimate antioxidant status using different biomarkers of oral submucous fibrosis concerning different stages of the disease in order to augment future therapy. Clinical relevance: Assessment of antioxidant activity helps to identify the patients at risk of malignant transformation. It serves as a reliable guide to validate therapy. It serves as a marker of prognosis in patients suffering from oral submucous fibrosis.

Indexed as

AntioxidantsOral precursor lesionsOral submucous fibrosisPotentially malignant disordersSuperoxide dismutase

Identifiers

PMID35498388
PMCPMC9048120
OpenAlexW4224145159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.