Evidence map›Paper›PMID 35498384›Full record

ArticleJTO clinical and research reports2022

Complete Remission After Immunotherapy-Induced Abdominal Tuberculosis in a Patient With Advanced NSCLC Treated With Pembrolizumab: A Case Report.

Mariona Riudavets, Benjamin Wyplosz, Maria Rosa Ghigna, Angela Botticella, Pamela Abdayem, Pauline Pradere, Ines Kasraoui, Charles Roux, Cécile Le Pechoux, Camilo Garcia and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in JTO clinical and research reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mariona RiudavetsCancer Medicine Department, Gustave Roussy Cancer Campus, Villejuif, France.
Benjamin WyploszInfectious Diseases Department, Hôpital Bicêtre-AP-HP, Le Kremlin Bicêtre, France.
Maria Rosa GhignaPathology Department, Gustave Roussy Cancer Campus, Villejuif, France.
Angela BotticellaRadiation Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France.
Pamela AbdayemCancer Medicine Department, Gustave Roussy Cancer Campus, Villejuif, France.
Pauline PraderePneumologie Department, Hôpital Marie Lannelongue, Plessis-Robinson, France.
Ines KasraouiRadiology Department, Gustave Roussy Cancer Campus, Villejuif, France.
Charles RouxInterventional Radiology Department, Gustave Roussy Cancer Campus, Villejuif, France.
Cécile Le PechouxRadiation Oncology Department, Gustave Roussy Cancer Campus, Villejuif, France.
Camilo GarciaNuclear Medicine Department, Gustave Roussy Cancer Campus, Villejuif, France.
David PlanchardCancer Medicine Department, Gustave Roussy Cancer Campus, Villejuif, France.
Institut Gustave Roussy · FRAssistance Publique – Hôpitaux de Paris · FRHôpital Marie Lannelongue · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of immune checkpoint inhibitors (ICIs) has drastically transformed the therapeutic landscape in lung cancer. Special focus has been put on immune-related toxicity; however, infections can also seem during ICI treatment. Although rare, tuberculosis (TB) has been increasingly identified after ICIs, and it seems that the programmed cell death protein 1 and programmed death-ligand 1 pathway is directly involved in its pathophysiology. Here, we describe the case of a patient with advanced NSCLC who developed abdominal TB after 32 months of pembrolizumab and who remains in tumor remission 10 months after discontinuation of this drug. Routine screening for latent TB before ICI treatment is advised, with closer collaboration between infectious disease specialists and oncologists.

Indexed as

Case reportImmune-checkpoint inhibitorsNon–small cell lung cancerTuberculosis

Identifiers

PMID35498384
PMCPMC9052143
OpenAlexW4220989338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.