Evidence map›Paper›PMID 35498312›Full record

ArticleRSC advances2020

Hybrid microchannel-solid state micropore device for fast and optical cell detection.

Carol M Olmos, Gustavo Rosero, Tamara Fernández-Cabada, Ross Booth, Manuel Der, Juan M Cabaleiro, Alexis Debut, Luis Cumbal, Maximiliano S Pérez, Betiana Lerner

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 6 countries.

Carol M OlmosFacultad Regional Haedo, Universidad Tecnológica Nacional (UTN) Haedo E 1706 Argentina belerner@fiu.edu mperez@frh.utn.edu.ar.
Gustavo RoseroFacultad Regional Haedo, Universidad Tecnológica Nacional (UTN) Haedo E 1706 Argentina belerner@fiu.edu mperez@frh.utn.edu.ar.
Tamara Fernández-CabadaFacultad Regional Haedo, Universidad Tecnológica Nacional (UTN) Haedo E 1706 Argentina belerner@fiu.edu mperez@frh.utn.edu.ar.
Ross BoothMilliporeSigma Corporation Hayward CA 94545 USA.
Manuel DerDepartamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Cuidad Universitaria Buenos Aires 1428 Argentina.
Juan M CabaleiroCONICET-Fluid Dynamics Laboratory, Facultad de ingeniería, Universidad de Buenos Aires (UBA) Buenos Aires C1063ACV Argentina.ORCID https://orcid.org/0000-0003-4127-0085
Alexis DebutCentro de Nanociencia y Nanotecnología, Universidad de las Fuerzas Armadas ESPE P. O. Box 171-5-231B Sangolquí Ecuador.
Luis CumbalCentro de Nanociencia y Nanotecnología, Universidad de las Fuerzas Armadas ESPE P. O. Box 171-5-231B Sangolquí Ecuador.
Maximiliano S PérezFacultad Regional Haedo, Universidad Tecnológica Nacional (UTN) Haedo E 1706 Argentina belerner@fiu.edu mperez@frh.utn.edu.ar.
Betiana LernerFacultad Regional Haedo, Universidad Tecnológica Nacional (UTN) Haedo E 1706 Argentina belerner@fiu.edu mperez@frh.utn.edu.ar.ORCID https://orcid.org/0000-0003-3341-5686
National Technological University · ARUniversidad de las Fuerzas Armadas ESPE · ECConsejo Nacional de Investigaciones Científicas y Técnicas · ARLine Corporation (Japan) · JPUniversidad de Buenos Aires · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This paper presents a methodology for cell detection and counting using a device that combines PDMS (polydimethylsiloxane) microfluidic multilayer channels with a single solid state micropore. Optimal conditions of solid-state micropore fabrication from crystalline silicon wafers are presented. Micropores of varying size can be obtained by directly etching using an etchant agent concentration of 50 wt% KOH, at varying temperatures (40, 60, 80 °C) and voltages (100, 500, 1000 mV). Scanning Electron Microscopy (SEM), and profilometry techniques have been used for the micropore characterization. In order to find optimal conditions for cell detection a COMSOL Multiphysics simulation was performed. Pressure drop, shear stress, fluid viscosities and flow rates parameters were evaluated. The potential viability of the device for cell detection and counting, avoiding cellular damage, is demonstrated.

Identifiers

PMID35498312
PMCPMC9049143
OpenAlexW3003364754

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.