Evidence map›Paper›PMID 35498291›Full record

ArticleRSC advances2020

Antimicrobial activity of multifaceted lactoferrin or graphene oxide functionalized silver nanocomposites biosynthesized using mushroom waste and chitosan.

Sundos Suleman Ismail Abdalla, Haliza Katas, Jie Yee Chan, Pavitra Ganasan, Fazren Azmi, Mohd Fauzi Mh Busra

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 51 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 4 countries.

Sundos Suleman Ismail AbdallaCentre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz Kuala Lumpur 50300 Malaysia haliza.katas@ukm.edu.my +60-3-26983271 +60-3-92897971.
Haliza KatasCentre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz Kuala Lumpur 50300 Malaysia haliza.katas@ukm.edu.my +60-3-26983271 +60-3-92897971.ORCID https://orcid.org/0000-0001-7249-1628
Jie Yee ChanCentre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz Kuala Lumpur 50300 Malaysia haliza.katas@ukm.edu.my +60-3-26983271 +60-3-92897971.
Pavitra GanasanCentre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz Kuala Lumpur 50300 Malaysia haliza.katas@ukm.edu.my +60-3-26983271 +60-3-92897971.
Fazren AzmiCentre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Jalan Raja Muda Abdul Aziz Kuala Lumpur 50300 Malaysia haliza.katas@ukm.edu.my +60-3-26983271 +60-3-92897971.
Mohd Fauzi Mh BusraTissue Engineering Centre, UKM Medical Centre 56000 Cheras Kuala Lumpur Malaysia.
Centre for Drug Research and Development · CAUniversity Kebangsaan Malaysia Medical Centre · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hybrid nanoparticles designed to exert multiple mechanisms of antibacterial action offer a new approach to the fight against pathogenic resistant bacteria. In this study, nanomaterials with the dual actions of antibacterial and anti-biofilm activities were developed using silver nanoparticles (AgNPs) functionalized with either lactoferrin (LTF) or graphene oxide (GO). AgNPs were synthesized using mushroom waste as a reducing agent and chitosan (CS) as a stabilizing agent, prior to their surface functionalization with either GO (AgGO) or LTF (Ag-LTF). The AgNPs exhibited a surface plasmon resonance (SPR) band at 430 nm, as determined by UV-vis spectroscopy, whereas the absorption of AgGO and Ag-LTF occurred at 402 and 441 nm, respectively. Particle size analysis of AgNPs, AgGO, and Ag-LTF revealed sizes of 121.5 ± 10.5, 354.0 ± 1.6, and 130.8 ± 1.2 nm, respectively. All AgNPs, Ag-LTF, and AgGO inhibited selected Gram-positive bacteria and Gram-negative bacteria with comparable antibacterial performance, as determined by the agar diffusion method. Despite the absence of antibacterial activity by GO and LTF, a synergistic effect of AgGO and Ag-LTF was observed as they had a greater activity against

Identifiers

PMID35498291
PMCPMC9049173
OpenAlexW3004372694

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.