Evidence map›Paper›PMID 35498225›Full record

ArticleSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society2022

Study of influence of

Hassan A Alhazmi, Mustafa A Bakri, Yahya A Mohzari, Yousef G Alshigaify, Mohammed Al Bratty, Sadique A Javed, Asim Najmi, Ziaur Rehman, Waquar Ahsan, Manal Mohamed Elhassan Taha

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hassan A AlhazmiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan P.O. Box 114, 45142, Saudi Arabia.
Mustafa A BakriDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan P.O. Box 114, 45142, Saudi Arabia.
Yahya A MohzariDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan P.O. Box 114, 45142, Saudi Arabia.
Yousef G AlshigaifyDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan P.O. Box 114, 45142, Saudi Arabia.
Mohammed Al BrattyDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan P.O. Box 114, 45142, Saudi Arabia.
Sadique A JavedDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan P.O. Box 114, 45142, Saudi Arabia.
Asim NajmiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan P.O. Box 114, 45142, Saudi Arabia.
Ziaur RehmanDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan P.O. Box 114, 45142, Saudi Arabia.
Waquar AhsanDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan P.O. Box 114, 45142, Saudi Arabia.
Manal Mohamed Elhassan TahaSubstance Abuse and Toxicity Research Centre, Jazan University, P.O. Box 114, 45142 Jazan, Saudi Arabia.
Jazan University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Khat consumers might use a number of drugs for underlying conditions; however the potential drug-herb interaction between khat and other drugs including Irbesartan (IRB) is unknown. The present study was conducted to evaluate the effects of khat chewing on pharmacokinetic profile of IRB, a commonly available antihypertensive agent. The pharmacokinetic profile of orally administered IRB (15.5 mg/kg) with and without pre-administration of khat (12.4 mg/kg) were determined in Sprague-Dawley rats. IRB was estimated in rat plasma samples using a newly developed HPLC method. The chromatographic separation of the drug and internal standard (IS) was performed on a C-18 column (Raptor C-18, 100 mm × 4.6 mm id.; 5 µm) using a mobile phase consisting of 10 mM ammonium acetate buffer (pH 4.0) and acetonitrile in a ratio 60:40

Indexed as

Cytochrome P450HPLCIrbesartanKhatPharmacokinetics

Identifiers

PMID35498225
PMCPMC9051964
OpenAlexW4205260309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.