Evidence map›Paper›PMID 35498133›Full record

ArticleOxidative medicine and cellular longevity2022

Association of the Combined Effects between Insulin-Like Growth Factor-1 Gene Polymorphisms and Negative Life Events with Major Depressive Disorder among Chinese population in the Context of Oxidative Stress.

Zhengxue Qiao, Yunjia Xie, Yongmei Wu, Xiuxian Yang, Xiaohui Qiu, Jiawei Zhou, Yuxin Lu, Lu Chen, Yuying Tong, Jia Xu and 6 more

Open access · hybridAbstract read
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In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Zhengxue QiaoDepartment of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0002-4485-1443
Yunjia XieDepartment of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0002-9909-0661
Yongmei WuDepartment of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0003-4305-5370
Xiuxian YangDepartment of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0002-0516-056X
Xiaohui QiuDepartment of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0001-9985-8231
Jiawei ZhouDepartment of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0002-5117-1825
Yuxin LuDepartment of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0001-8005-2385
Lu ChenBeijing Hospital, Beijing, China.
Yuying TongDepartment of Psychology, School of Education of Heilongjiang University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0002-0567-0666
Jia XuThe First Psychiatric Hospital of Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0002-0505-8055
Jiarui LiDepartment of Medical Education Management, Harbin Medical University, Harbin, China.ORCID https://orcid.org/0000-0002-1135-2736
Jingyun HeDepartment of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0001-8258-4780
Hui PanDepartment of Endocrinology, Peking Union Medical College Hospital, Beijing, China.
Yanjie YangDepartment of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0002-8638-5313
Jiarun YangDepartment of Psychology, School of Education of Heilongjiang University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0002-7879-3923
Tianyi BuDepartment of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.ORCID https://orcid.org/0000-0003-4134-8858
Harbin Medical University · CNHeilongjiang University · CNBeijing Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oxidative stress may be increased in a number of psychiatric disorders, including major depressive disorder (MDD). MDD has been shown to be related to insulin-like growth factor-1 (IGF-1) as well as to negative life events; exploring the interaction of IGF-1 polymorphisms and negative life events on the risk of MDD is needed. The aim of this study was to analyze the single and combined effects of IGF-1 polymorphisms (rs972936 and rs978458) and negative life events with MDD among Chinese population. Methods: 420 MDD patients (according to DSM-V) and 420 age- and gender-matched control subjects were recruited in a case-control study. Negative life events were assessed using standard rating scales. IGF-1 rs972936 and rs978458 were identified by sequencing. The chi-square ( Results: Our results found that the negative life events were associated with the risk of MDD ( Conclusions: Based on the oxidative stress hypothesis, we confirm that carrying IGF-1 rs972936 C allele and rs978458 T allele have a higher risk of MDD and the combined effects between IGF-1 rs978458 and negative life events were associated with the risk of MDD among Chinese population.

Indexed as

Major Depressive DisorderCase-Control StudiesChinaHumansInsulin-Like Growth Factor IOxidative StressPolymorphism, GeneticIGF1 protein, humanInsulin-Like Growth Factor I

Identifiers

PMID35498133
PMCPMC9054463
OpenAlexW4224229191

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.