Evidence map›Paper›PMID 35498024›Full record

ArticleFrontiers in cardiovascular medicine2022

Effects of Excessive Activation of N-methyl-D-aspartic Acid Receptors in Neonatal Cardiac Mitochondrial Dysfunction Induced by Intrauterine Hypoxia.

Yang Liu, Ziqiang Luo, Zhengchang Liao, Mingjie Wang, Yan Zhou, Siwei Luo, Ying Ding, Teng Liu, Chuangding Cao, Shaojie Yue

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023
    Article
  2. Review
  3. Exploring the Association between Oxygen Concentration and Life Expectancy in China: A Quantitative Analysis.International journal of environmental research and public health · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yang LiuDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha, China.
Ziqiang LuoDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, China.
Zhengchang LiaoDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha, China.
Mingjie WangDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha, China.
Yan ZhouDepartment of Physiology, Xiangya School of Medicine, Central South University, Changsha, China.
Siwei LuoDepartments of Pediatrics and Neonatology, Children's Hospital of Fudan University, Shanghai, China.
Ying DingDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha, China.
Teng LiuDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha, China.
Chuangding CaoDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha, China.
Shaojie YueDepartment of Neonatology, Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNXiangya Hospital Central South University · CNChildren's Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrauterine hypoxia is a common complication during pregnancy and could increase the risk of cardiovascular disease in offspring. However, the underlying mechanism is controversial. Memantine, an NMDA receptor antagonist, is reported to be a potential cardio-protective agent. We hypothesized that antenatal memantine treatment could prevent heart injury in neonatal offspring exposed to intrauterine hypoxia. Pregnant rats were exposed to gestational hypoxia or antenatal memantine treatment during late pregnancy. Newborns were then sacrificed to assess multiple parameters. The results revealed that Intrauterine hypoxia resulted in declining birth weight, heart weight, and an abnormally high heart weight/birth weight ratio. Furthermore, intrauterine hypoxia caused mitochondrial structural, functional abnormalities and decreased expression of DRP1, and upregulation of NMDAR1

Indexed as

intrauterine hypoxiamitochondrial dynamicsmitochondrial dysfunctionneonatal rat heartN-methyl-D-aspartic acid receptors

Identifiers

PMID35498024
PMCPMC9039344
OpenAlexW4220800073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.