Evidence map›Paper›PMID 35497910›Full record

ArticleAging pathobiology and therapeutics2022

Geropathology. An inside view of biological aging.

Warren Ladiges

Abstract read
In one paragraph

Article in Aging pathobiology and therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Warren LadigesDepartment of Comparative Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA.

Funding

Physical resilience is a predictor of healthy aging in miceR01AG057381 · NIA · UNIVERSITY OF WASHINGTON · PI Warren C LADIGES · 2017 to 2026
$4.6M
A geroscience approach for treating Alzheimer's diseaseR01AG067193 · NIA · UNIVERSITY OF WASHINGTON · PI DARVAS, MARTIN C, LADIGES, WARREN C · 2020 to 2024
$4.4M
Pathology of Aging Research NetworkR24AG047115 · NIA · UNIVERSITY OF WASHINGTON · PI LADIGES, WARREN C · 2014 to 2016
$1.1M
NIA NIH HHS R01 AG057381NIA NIH HHS R01 AG067193NIA NIH HHS R24 AG047115
6 · The paper itself

Abstract

The geropathology concept assumes all age-related lesions are relevant, which allows the ability to grade each lesion in an organ with a severity score resulting in a quantitative value. Because aging pet cats have similar age-related diseases as older humans, knowledge of histopathology occurring during aging would be invaluable to determine how age-related lesions progress with increasing age and the connection with comorbidities. The ability to use the severity of specific organ geropathology to predict biological aging would provide new approaches to study pathways of aging and their role in the development of age-related diseases in animal models.

Indexed as

age-related diseasesage-related lesionsAlzheimer’s diseasedomestic catsGeropathologypathways of agingstandard lesion curve

Identifiers

PMID35497910
PMCPMC9053873

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.