Evidence map›Paper›PMID 35497848›Full record

ArticleRSC advances2020

Selection and application of aptamers with high-affinity and high-specificity against dinophysistoxin-1.

Zhen Li, Bo Hu, Rong Zhou, Xiaojuan Zhang, Ruizhe Wang, Yun Gao, Mingjuan Sun, Binghua Jiao, Lianghua Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Zhen LiDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Navy Medical University Shanghai 200433 P. R. China bhjiao@smmu.edu.cn lhwang@smmu.edu.cn.ORCID https://orcid.org/0000-0002-5401-1835
Bo HuDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Navy Medical University Shanghai 200433 P. R. China bhjiao@smmu.edu.cn lhwang@smmu.edu.cn.
Rong ZhouDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Navy Medical University Shanghai 200433 P. R. China bhjiao@smmu.edu.cn lhwang@smmu.edu.cn.ORCID https://orcid.org/0000-0002-7740-5378
Xiaojuan ZhangDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Navy Medical University Shanghai 200433 P. R. China bhjiao@smmu.edu.cn lhwang@smmu.edu.cn.
Ruizhe WangSpine Center, Department of Orthopedics, Changzheng Hospital Affiliated to Second Military Medical University 415th Feng Yang Road Shanghai 200003 P. R. China.
Yun GaoDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Navy Medical University Shanghai 200433 P. R. China bhjiao@smmu.edu.cn lhwang@smmu.edu.cn.
Mingjuan SunDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Navy Medical University Shanghai 200433 P. R. China bhjiao@smmu.edu.cn lhwang@smmu.edu.cn.
Binghua JiaoDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Navy Medical University Shanghai 200433 P. R. China bhjiao@smmu.edu.cn lhwang@smmu.edu.cn.
Lianghua WangDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Navy Medical University Shanghai 200433 P. R. China bhjiao@smmu.edu.cn lhwang@smmu.edu.cn.
College of Medical Sciences · NPSecond Military Medical University · CNShaoxing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diarrhetic shellfish toxins (DSTs) are marine toxins distributed widely in the world, which pose a major threat to the health of mankind. Dinophysistoxin-1 (DTX-1) has the most potent toxicity in DSTs. However, the current detection methods have ethical problems and technical defects. Further research is needed, to develop a more suitable alternative to the supervision system. In this work, we successfully obtained an aptamer with high affinity and specificity bound to DTX-1 for the first time. After optimization, a core sequence of the aptamer with a higher

Identifiers

PMID35497848
PMCPMC9049938
OpenAlexW3008383025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.