Evidence map›Paper›PMID 35497809›Full record

ArticleKidney international reports2022

Retinal Drusen Are More Common and Larger in Systemic Lupus Erythematosus With Renal Impairment.

Ye Ji Ham, Eleanor Nicklason, Tony Wightman, Sarah Akom, Kieran Sandhu, Philip Harraka, Deb Colville, Andrew Catran, David Barit, David Langsford and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Ye Ji HamThe University of Melbourne Department of Medicine, Northern Health and Melbourne Health, Melbourne, Australia.
Eleanor NicklasonThe University of Melbourne Department of Medicine, Northern Health and Melbourne Health, Melbourne, Australia.
Tony WightmanThe University of Melbourne Department of Medicine, Northern Health and Melbourne Health, Melbourne, Australia.
Sarah AkomThe University of Melbourne Department of Medicine, Northern Health and Melbourne Health, Melbourne, Australia.
Kieran SandhuThe University of Melbourne Department of Medicine, Northern Health and Melbourne Health, Melbourne, Australia.
Philip HarrakaThe University of Melbourne Department of Medicine, Northern Health and Melbourne Health, Melbourne, Australia.
Deb ColvilleThe University of Melbourne Department of Medicine, Northern Health and Melbourne Health, Melbourne, Australia.
Andrew CatranThe University of Melbourne Department of Medicine, Northern Health and Melbourne Health, Melbourne, Australia.
David BaritRenal Unit, Northern Health, Melbourne, Australia.
David LangsfordRenal Unit, Northern Health, Melbourne, Australia.
Tim PiantaRenal Unit, Northern Health, Melbourne, Australia.
Andrew FooteRheumatology Unit, Northern Health, Melbourne, Australia.
Russell BuchananRheumatology Unit, Northern Health, Melbourne, Australia.
Heather MackThe University of Melbourne Department of Ophthalmology, The Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Judy SavigeThe University of Melbourne Department of Medicine, Northern Health and Melbourne Health, Melbourne, Australia.
The University of Melbourne · AUNorthern Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Complement has been implicated in systemic lupus erythematosus (SLE) pathogenesis on the basis of the associations with inherited complement defects and genome-wide association study risk alleles, glomerular deposits, reduced serum levels, and occasional reports of retinal drusen. This study examined drusen in SLE and their clinical significance. Methods: This cross-sectional observational study compared individuals with SLE recruited from renal and rheumatology clinics with hospital controls. Participants were reviewed for clinical features and underwent imaging with a nonmydriatic retinal camera. Deidentified images were examined by 2 trained graders for drusen number and size using a grid overlay. Results: The cohort with SLE ( Conclusion: Drusen composition resembles that of glomerular immune deposits. CFH controls complement activation in the extracellular matrix and

Indexed as

complementdrusenimmune complexesimpaired kidney functionlupus nephritisSLE

Identifiers

PMID35497809
PMCPMC9039474
OpenAlexW4210533151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.