Evidence map›Paper›PMID 35497786›Full record

ArticleKidney international reports2022

Kidney Transplant Outcomes of Patients With Multiple Myeloma.

Cihan Heybeli, Andrew J Bentall, Mariam Priya Alexander, Hatem Amer, Francis K Buadi, Angela Dispenzieri, David Dingli, Morie A Gertz, Naim Issa, Prashant Kapoor and 6 more

Abstract read
In one paragraph

Article in Kidney international reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Cihan HeybeliDivision of Nephrology, Muş State Hospital, Muş, Turkey.
Andrew J BentallDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Mariam Priya AlexanderDepartment of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Hatem AmerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Francis K BuadiDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Angela DispenzieriDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
David DingliDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Morie A GertzDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Naim IssaDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Prashant KapoorDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Aleksandra KuklaDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Shaji KumarDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Elizabeth C LorenzDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
S Vincent RajkumarDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Carrie A SchinstockDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.
Nelson LeungDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Funding

Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Peter Leif Bergsagel · 2015 to 2026
$25.5M
Improving frailty and long-term outcomes after kidney transplantationK23DK123313 · NIDDK · MAYO CLINIC ROCHESTER · PI LORENZ, ELIZABETH C. · 2019 to 2023
$795k
NCI NIH HHS P50 CA186781NIDDK NIH HHS K23 DK123313
6 · The paper itself

Abstract

Introduction: Data on kidney transplantation (KTx) outcomes of patients with multiple myeloma (MM) are very limited. Methods: We investigated the outcomes of patients with MM who underwent KTx between 1994 and 2019. Results: A total of 12 transplants from 11 patients were included. At the time of KTx, 6 were classified as having stringent complete response (CR), 2 as CR, 2 as very good partial response (VGPR), and 2 as partial response (PR). With a median follow-up of 40 (minimum-maximum, 5-92) months after KTx, hematologic progression occurred in 9 transplants (75%). There were 3 grafts (25%) that failed, and 5 patients (45.5%) experienced death with functioning allografts. Graft survival at 1 and 5 years was 82.5% and 66%, respectively. Progression-free survival (PFS) rates of the cohort at 1, 3, and 5 years were 83.3%, 55.6%, and 44.4%, respectively. The estimated median PFS of patients who received bortezomib at any time (pre-KTx and/or post-KTx) was not reached, whereas it was 24 months for those who never received bortezomib ( Conclusion: Kidney transplant outcomes of patients with myeloma who received bortezomib before or after KTx seem to be more favorable. Nevertheless, relapse after KTx in MM is still common. More studies are needed to better determine who benefits from a KTx.

Indexed as

chronic kidney failuregraft survivalkidney transplantationmortalitymultiple myelomarecurrence

Identifiers

PMID35497786
PMCPMC9039485

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.