ArticleRSC advances2020
Bifunctional phase-transfer catalysts for synthesis of 2-oxazolidinones from isocyanates and epoxides.
Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Chiral bifunctional organocatalysts for enantioselective synthesis of 3-substituted isoindolinones.RSC advances · 2023Article
- Synthesis of Novel Crown Ether-Squaramides and Their Application as Phase-Transfer Catalysts.Molecules (Basel, Switzerland) · 2021Article
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6 authors.
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Abstract
A series of bifunctional phase-transfer catalysts (PTCs) were synthesized to catalyze the [3 + 2] coupling reaction of isocyanates and epoxides to afford 2-oxazolidinones in good to high yields (up to 92% yield) using PhCl as a solvent at 100 °C within 12 h. These bifunctional PTCs were easily prepared from commercially available tertiary-primary diamines and isocyanates (or isothiocyanates, mono-squaramides, respectively) in two simple steps with good modularity and demonstrated high efficiency (2.5 mol% catalyst-loading). The synergistic interaction of the quaternary ammonium salt center and hydrogen-bond donor group in the catalyst with the substrate is crucial to this atom-economic reaction.
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