Evidence map›Paper›PMID 35497517›Full record

ArticleRSC advances2021

Development of a pH-sensitive functionalized metal organic framework:

Ragini Singh, Binayak Kumar, Ram Krishna Sahu, Soni Kumari, Chandan Bhogendra Jha, Nahar Singh, Rashi Mathur, Suresh T Hedau

Open access · goldAbstract read
In one paragraph

Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ragini SinghDivision of Molecular Oncology, ICMR-National Institute of Cancer Prevention and Research I-7, Sector 39, Gautam Buddha Nagar Noida-201301 U.P. India suresh.hedau@gov.in +91-0120-2446909.
Binayak KumarDivision of Molecular Oncology, ICMR-National Institute of Cancer Prevention and Research I-7, Sector 39, Gautam Buddha Nagar Noida-201301 U.P. India suresh.hedau@gov.in +91-0120-2446909.
Ram Krishna SahuDivision of Molecular Oncology, ICMR-National Institute of Cancer Prevention and Research I-7, Sector 39, Gautam Buddha Nagar Noida-201301 U.P. India suresh.hedau@gov.in +91-0120-2446909.
Soni KumariDivision of Molecular Oncology, ICMR-National Institute of Cancer Prevention and Research I-7, Sector 39, Gautam Buddha Nagar Noida-201301 U.P. India suresh.hedau@gov.in +91-0120-2446909.
Chandan Bhogendra JhaDivision of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Defense Research and Development Organization Brig. S.K. Mazumdar Marg Delhi 110054 India.
Nahar SinghCSIR-National Physical Laboratory New Delhi 110012 India.
Rashi MathurDivision of Cyclotron and Radiopharmaceutical Sciences, Institute of Nuclear Medicine and Allied Sciences, Defense Research and Development Organization Brig. S.K. Mazumdar Marg Delhi 110054 India.
Suresh T HedauDivision of Molecular Oncology, ICMR-National Institute of Cancer Prevention and Research I-7, Sector 39, Gautam Buddha Nagar Noida-201301 U.P. India suresh.hedau@gov.in +91-0120-2446909.ORCID https://orcid.org/0000-0002-9576-1341
National Institute of Cancer Prevention and Research · INInstitute of Nuclear Medicine & Allied Sciences · INCSIR National Physical Laboratory of India · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exploration of an efficient dual-drug based nanocarrier with high drug loading capacity, specific targeting properties, and long-term stability is highly desirable in cancer therapy. Metal-organic frameworks (MOFs) have proven to be a promising class of drug carriers due to their high porosity, crystalline properties with defined structure information, and their potential for further functionalization. To enhance the drug efficacy as well as to overcome the burst effect of drugs, here we synthesized a pH responsive folic acid (FA) and graphene oxide (GO) decorated zeolitical imidazolate frameworks-8 (GO-FA/ZIF-8), for targeted delivery of doxorubicin (DOX) and cyclophosphamide (CP), simultaneously. In this system, DOX molecules were encapsulated in the pores of ZIF-8 during

Identifiers

PMID35497517
PMCPMC9042314
OpenAlexW3206084158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.