Evidence map›Paper›PMID 35497514›Full record

ArticleRSC advances2021

A highly selective quinolizinium-based fluorescent probe for cysteine detection.

Wa-Yi O, Wing-Cheung Chan, Caifeng Xu, Jie-Ren Deng, Ben Chi-Bun Ko, Man-Kin Wong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Wa-Yi OThe Hong Kong Polytechnic University, Shenzhen Research Institute Shenzhen P. R. China mankin.wong@polyu.edu.hk.
Wing-Cheung ChanState Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hung Hom Hong Kong P. R. China mankin.wong@polyu.edu.hk ben.ko@polyu.edu.hk.
Caifeng XuThe Hong Kong Polytechnic University, Shenzhen Research Institute Shenzhen P. R. China mankin.wong@polyu.edu.hk.
Jie-Ren DengState Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hung Hom Hong Kong P. R. China mankin.wong@polyu.edu.hk ben.ko@polyu.edu.hk.
Ben Chi-Bun KoState Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University Hung Hom Hong Kong P. R. China mankin.wong@polyu.edu.hk ben.ko@polyu.edu.hk.
Man-Kin WongThe Hong Kong Polytechnic University, Shenzhen Research Institute Shenzhen P. R. China mankin.wong@polyu.edu.hk.ORCID https://orcid.org/0000-0003-1574-6860
Hong Kong Polytechnic University · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel fluorescent quinolizinium-based turn-off probe has been developed for selective detection of cysteine. The probe showed high selectivity and sensitivity towards cysteine over other amino acids including the similarly structured homocysteine and glutathione with a detection limit of 0.18 μM (S/N = 3). It was successfully applied to cysteine detection in living cells with low cytotoxicity and quantitative analysis of spiked mouse serum samples with moderate to good recovery (96-109%).

Identifiers

PMID35497514
PMCPMC9042279
OpenAlexW3207738110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.