Evidence map›Paper›PMID 35497503›Full record

ArticleMolecular therapy. Nucleic acids2022

What goes around comes around: Artificial circular RNAs bypass cellular antiviral responses.

Janina Breuer, Patrick Barth, Yannic Noe, Lyudmila Shalamova, Alexander Goesmann, Friedemann Weber, Oliver Rossbach

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Dual-functional nanoplatform for simultaneous degradation of circRNAJournal of Zhejiang University. Science. B · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. The therapeutic potential of circular RNAs.Nature reviews. Genetics · 2025
    Review
  10. Nucleic acid therapeutics: Past, present, and future.Molecular therapy. Nucleic acids · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Challenges and Future Prospectives in Circular RNA Investigation.Advances in experimental medicine and biology · 2025
    Review
  15. Review
  16. Article
  17. Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Janina BreuerInstitute of Biochemistry, Faculty of Biology and Chemistry (FB08), Justus-Liebig-University of Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Patrick BarthBioinformatics and Systems Biology, University of Giessen, Heinrich-Buff-Ring 58, 35392 Giessen, Germany.
Yannic NoeInstitute of Biochemistry, Faculty of Biology and Chemistry (FB08), Justus-Liebig-University of Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Lyudmila ShalamovaInstitute for Virology, Faculty of Veterinary Medicine, University of Giessen, Schubertstr. 81, 35392 Giessen, Germany.
Alexander GoesmannBioinformatics and Systems Biology, University of Giessen, Heinrich-Buff-Ring 58, 35392 Giessen, Germany.
Friedemann WeberInstitute for Virology, Faculty of Veterinary Medicine, University of Giessen, Schubertstr. 81, 35392 Giessen, Germany.
Oliver RossbachInstitute of Biochemistry, Faculty of Biology and Chemistry (FB08), Justus-Liebig-University of Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany.
Justus-Liebig-Universität Gießen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural circular RNAs have been found to sequester microRNAs and suppress their function. We have used this principle as a molecular tool and produced artificial circular RNA sponges in a cell-free system by

Indexed as

artificial circRNAcircular RNAcircular RNA spongesimmunogenicityinnate immune responsemolecular spongeMT: Non-coding RNAsRNA sensorsRNA therapysensory molecules

Identifiers

PMID35497503
PMCPMC9042720
OpenAlexW4224924667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.