ArticleRSC advances2020
Enhancing cellular morphological changes and ablation of cancer cells
Article in RSC advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- Cellular and Molecular Effects of Magnetic Fields.International journal of molecular sciences · 2024Review
- Superparamagnetic Artificial Cells PLGA-FeCancers · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Magnetic nanoparticles have been widely used in cancer treatment for their potential magnetic functions and synergistic antitumor effect with therapeutic agents. In this work, we developed a polymeric nanosystem by co-loading the natural anticancer drug tetrandrine and superparamagnetic iron oxide nanoparticles for cancer combinatorial therapy. The nanosystem possessed regular morphology and superior magnetic properties. Under the action of external rotating permanent magnets, the nanosystem could transfer a rotational motion to damage the cellular membrane, which would result in the increased permeabilization of the cell membrane and damage to lysosomes. Hence, the specific characteristics of the magnetic nanosystem induced potent cytotoxicity and enhanced the effect of the tetrandrine-induced cell apoptosis. With further exploration, we found that this nanoplatform caused cell death
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.