Evidence map›Paper›PMID 35496999›Full record

ArticleiScience2022

Familial natural short sleep mutations reduce Alzheimer pathology in mice.

Qing Dong, Nicholas W Gentry, Thomas McMahon, Maya Yamazaki, Lorena Benitez-Rivera, Tammy Wang, Li Gan, Louis Ptáček, Ying-Hui Fu

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Emerging genetics of sleep and circadian disorders.Current opinion in pediatrics · 2026
    Article
  2. Article
  3. Prime editing of the βNature communications · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Mutant βProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Healthy Sleep Every Day Keeps the Doctor Away.International journal of environmental research and public health · 2022
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Qing DongDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
Nicholas W GentryDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
Thomas McMahonDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
Maya YamazakiDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
Lorena Benitez-RiveraDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
Tammy WangDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
Li GanHelen & Robert Appel Alzheimer's Disease Research Institute, Weill Cornell Medicine, New York, NY 10021, USA.
Louis PtáčekDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
Ying-Hui FuDepartment of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
University of California, San Francisco · USCornell University · US

Funding

Probing genetics and biology of human sleep homeostasisR01NS117929 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PTACEK, LOUIS J. · 2021 to 2025
$3.3M
Investigating the neurocircuitry of sleep duration regulationR01NS104782 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FU, YING-HUI · 2018 to 2022
$3.0M
Investigating Genetics of Human Natural Short SleepersR01NS072360 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FU, YING-HUI · 2011 to 2015
$2.2M
The role of DEC2 and sleep in prevention of Alzheimer like pathologyRF1AG054606 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FU, YING-HUI · 2017 to 2017
$2.0M
NIA NIH HHS RF1 AG054606NINDS NIH HHS R01 NS072360NINDS NIH HHS R01 NS104782NINDS NIH HHS R01 NS117929
6 · The paper itself

Abstract

Although numerous studies have demonstrated that poor sleep increases the development of AD, direct evidence elucidating the benefits of good sleep on the AD pathogenesis is lacking. Familial Natural Short Sleepers (FNSS) are genetically wired to have lifelong reduction in nightly sleep duration without evident consequence on cognitive demise, implying that they may have better sleep quality. Here we investigated two FNSS mutations,

Indexed as

Behavioral neuroscienceBiological sciencesMolecular neuroscience

Identifiers

PMID35496999
PMCPMC9042888
OpenAlexW4220964691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.