ArticleiScience2022
Oxytocin promotes social proximity and decreases vigilance in groups of African lions.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Natural variation in the oxytocin receptor gene predicts social observation in female prairie voles.bioRxiv : the preprint server for biology · 2025Article
- Development of a Methodology for Measuring Oxytocin in Feces: Insights from a Preliminary Study in Captive Lions (Animals : an open access journal from MDPI · 2025Article
- Oxytocin reduces asymmetries in dominance relationships between pairs of captive female lions.Scientific reports · 2025Article
- Interspecies Relational Theory: A Framework for Compassionate Interspecies Interactions.Veterinary sciences · 2025Review
- Oxytocin activity is not linked to out-group prosociality in wild bonobos.Scientific reports · 2025Article
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- Article
- Mechanisms of social behaviour in the anti-social blind cavefish (Proceedings. Biological sciences · 2025Article
- Oxytocin homogenizes horse group organization.iScience · 2024Article
- Exogenous oxytocin increases gaze to humans in male cats.Scientific reports · 2024Article
- An AAV-CRISPR/Cas9 strategy for gene editing across divergent rodent species: Targeting neural oxytocin receptors as a proof of concept.Science advances · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxytocin modulates mammalian social behavior; however, behavioral responses to intranasal oxytocin can vary across species and contexts. The complexity of social interactions increases with group dynamics, and the impacts of oxytocin on both within- and between-group contexts are unknown. We tested the effects of intranasal administration of oxytocin on social and non-social behaviors within in-group and out-group contexts in African lions. We hypothesized that, post intranasal oxytocin administration, lions would be in closer proximity with fellow group members, whereas out-group stimuli could either produce a heightened vigilance response or an attenuated one. Compared to control trials, post oxytocin administration, lions increased their time spent in close proximity (reducing their distance to the nearest neighbor) and decreased vigilance toward out-group intruders (reducing their vocalizations following a roar-playback). These results not only have important implications for understanding the evolution of social circuitry but may also have practical applications for conservation efforts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.