Evidence map›Paper›PMID 35496974›Full record

ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2022

The Clinical Efficacy of Epoetin Alfa and Darbepoetin Alfa in Patients with Low-Risk or Intermediate-1-Risk Myelodysplastic Syndrome: Retrospective Multi-center Real-Life Study.

Muzeyyen Aslaner Ak, Birsen Sahip, Ayfer Geduk, Mehmer Ali Ucar, Hacer Kale, Tugba Hacibekiroglu, Merve Gokcen Polat, Yasin Kalpakci, Ali Zahit Bolaman, Birol Guvenc and 1 more

Open access · greenAbstract read
In one paragraph

Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Muzeyyen Aslaner AkDepartment of Hematology, Zonguldak Bulent Ecevit University Faculty of Medicine, Incivez, 67100 Zonguldak, Turkey.ORCID 0000-0001-6621-3138
Birsen SahipDepartment of Hematology, Zonguldak Bulent Ecevit University Faculty of Medicine, Incivez, 67100 Zonguldak, Turkey.
Ayfer GedukDepartment of Hematology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Mehmer Ali UcarDepartment of Hematology, Cukurova University Faculty of Medicine, Adana, Turkey.
Hacer KaleDepartment of Hematology, Adnan Menderes University Faculty of Medicine, Aydin, Turkey.
Tugba HacibekirogluDepartment of Hematology, Sakarya Training and Research Hospital, Sakarya, Turkey.
Merve Gokcen PolatDepartment of Hematology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Yasin KalpakciDepartment of Hematology, Sakarya Training and Research Hospital, Sakarya, Turkey.
Ali Zahit BolamanDepartment of Hematology, Adnan Menderes University Faculty of Medicine, Aydin, Turkey.
Birol GuvencDepartment of Hematology, Cukurova University Faculty of Medicine, Adana, Turkey.
Sehmus ErtopDepartment of Hematology, Zonguldak Bulent Ecevit University Faculty of Medicine, Incivez, 67100 Zonguldak, Turkey.
Bülent Ecevit University · TRAdnan Menderes University · TRCukurova University · TRKocaeli Üniversitesi · TRSakarya Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the clinical efficacy of epoetin alfa and darbepoetin alfa in patients with myelodysplastic syndromes (MDS) in the real-life setting. A total of 204 patients with low-risk or intermediate-1-risk MDS who received epoetin alfa or darbepoetin alfa were included. Hemoglobin levels and transfusion need were recorded before and during 12-month treatment. Hemoglobin levels were significantly higher at each follow up visit when compared to baseline levels in both epoetin alfa (mean ± SD 8.68 ± 1.0 g/dL at baseline vs. 9.83 ± 1.45, 9.99 ± 1.55, 10.24 ± 1.77 and 10.2 ± 1.5 g/dL, respectively) and darbepoetin alfa (8.83 ± 1.09 g/dL at baseline vs. 9.62 ± 1.37, 9.78 ± 1.49, 9.9 ± 1.39 and 10.1 ± 1.5 g/dL, respectively) groups ( Supplementary Information: The online version contains supplementary material available at 10.1007/s12288-021-01458-1.

Indexed as

Darbepoetin alfaEpoetin alfaLow-risk-intermediate-1-riskMyelodysplastic syndromeTreatment response

Identifiers

PMID35496974
PMCPMC9001769
OpenAlexW3177390341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.