ArticleFrontiers in cellular neuroscience2022
Microglia Don't Treat All Neurons the Same: The Importance of Neuronal Subtype in Microglia-Neuron Interactions in the Developing Hypothalamus.
Article in Frontiers in cellular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Microglia Modulate Information Processing in the Mouse Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Cocaine-Induced Microglial Impairment and Its Rehabilitation by PLX-PAD Cell Therapy.International journal of molecular sciences · 2024Article
- Cells and circuits for amygdala neuroplasticity in the transition to chronic pain.Cell reports · 2024Article
- Stressed Microglia: Neuroendocrine-Neuroimmune Interactions in the Stress Response.Endocrinology · 2023Review
- Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Microglia are now well-known as integral regulators of brain development, phagocytosing whole neurons, and pruning weak or excess synapses in order to sculpt and refine immature circuits. However, the importance of neuronal subtype in guiding microglial activity has not received much attention until recently. This perspective will delineate what is known about this topic so far, starting with the developing brain as a whole and then focusing on the developing hypothalamus in particular. There is emerging evidence that subpopulations of microglia treat excitatory and inhibitory neurons differently, and our recent work has shown that even the type of neuropeptide produced by the nearby neurons is important. For example, microglia abutting corticotropin-releasing hormone (CRH)-expressing neurons in the paraventricular nucleus of the hypothalamus (PVN) engulf fewer excitatory synapses than do microglia on the borders of the PVN that are not contacting CRH+ neurons. Potential future directions and technical considerations will be discussed in an effort to catalyze this emerging and exciting area of research. Applications of this research may hold promise in creating more specific therapies that target unique subtypes of microglia-neuron interactions in the atypically developing brain.
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Registered trials
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