ArticleFrontiers in cellular neuroscience2022
Repetitive Transcranial Magnetic Stimulation Improves Neurological Function and Promotes the Anti-inflammatory Polarization of Microglia in Ischemic Rats.
Article in Frontiers in cellular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06940609 (Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation), which is not on this map. Cited by 36 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation (MANIFEST)
Who cites it
36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Effectiveness of non-pharmacological interventions for lower limb motor impairment in post-stroke hemiplegia: a systematic review and Bayesian network meta-analysis.Journal of neuroengineering and rehabilitation · 2026Pooled it
- Pooled it
- Status and trends in transcranial magnetic stimulation research: a bibliometric analysis.Frontiers in neurology · 2025Pooled it
- Emerging trends and research hotspots of non-invasive brain stimulation for stroke: a bibliometric and visualization study.Frontiers in neurology · 2025Pooled it
- Efficacy and safety of repetitive transcranial magnetic stimulation with different frequencies on neuropathic orofacial pain: a systematic literature review and meta-analysis.Journal of oral & facial pain and headache · 2024Pooled it
- Global research trends in transcranial magnetic stimulation for stroke (1994-2023): promising, yet requiring further practice.Frontiers in neurology · 2024Pooled it
- Trial
- LGALS9 Is Beneficial to the Therapeutic Effect of Repetitive Transcranial Magnetic Stimulation on Ischemic Stroke.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Precision in Delivery, Variability in Response: A Multiscale Mechanistic Framework for Neuronavigated Transcranial Magnetic Stimulation.Brain sciences · 2026Review
- Intermittent theta-burst stimulation promotes neurovascular unit remodeling after ischemic stroke in a mouse model.Neural regeneration research · 2026Article
- Trans-spinal magnetic stimulation upregulates microglial SOCS3 to attenuate neuroinflammation in chronic constriction injury-induced neuropathic pain.Neural regeneration research · 2026Article
- 1 Hz Low-Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Epilepsy by Suppressing Interferon-γ Signaling-Dependent Microglial Synaptic Phagocytosis in Mice.CNS neuroscience & therapeutics · 2026Article
- Repetitive trans-spinal magnetic stimulation promotes repair in inflammatory spinal cord injury through sex-dependent immune modulation.Journal of neuroinflammation · 2026Article
- Repetitive transcranial magnetic stimulation modulates neuroinflammation and cell apoptosis via the interaction between Ifit3 and Stat1 for the treatment of neuropathic pain.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Plasticity-Induced Motor Recovery of Bilateral Intermittent Theta Burst Stimulation in Parkinson's Disease: A Randomized, Double-Blind, Sham-Controlled, Crossover Trial.Neurology and therapy · 2026Article
- Neuroimaging-Guided Insights into the Molecular and Network Mechanisms of Chronic Pain and Neuromodulation.International journal of molecular sciences · 2026Review
- Screening the optimal rTSMS frequency to orchestrate immune-fibrotic remodeling for adult spinal cord repair.Frontiers in neuroscience · 2026Article
- rTMS for treatment resistant depression - a single center community experience.Frontiers in psychiatry · 2026Article
- Development of repetitive transcranial magnetic stimulation for central poststroke pain: A review.Medicine · 2025Review
- Immunity in neuromodulation: probing neural and immune pathways in brain disorders.Journal of neuroinflammation · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic stroke (IS) is a severe neurological disease that is difficult to recovery. Previous studies have shown that repetitive transcranial magnetic stimulation (rTMS) is a promising therapeutic approach, while the exact therapy mechanisms of rTMS in improving neural functional recovery remain unclear. Furthermore, the inflammatory environment may influence the rehabilitation efficacy. Our study shows that long-term rTMS stimulation will significantly promote neurogenesis, inhibit apoptosis, and control inflammation. rTMS inhibits the activation of transcription factors nuclear factor kappa b (NF-κB) and signal transducer and activator of transcription 6 (STAT6) and promotes the anti-inflammatory polarization of microglia. Obvious promotion of anti-inflammatory cytokines production is observed both
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.