Evidence map›Paper›PMID 35496826›Full record

ArticleAfrican journal of emergency medicine : Revue africaine de la medecine d'urgence2022

SARS-CoV-2 in children and their accompanying caregivers: Implications for testing strategies in resource limited hospitals.

Liezl Smit, Andrew Redfern, Sadia Murray, Juanita Lishman, Marieke M van der Zalm, Gert van Zyl, Lilly M Verhagen, Corné de Vos, Helena Rabie, Annemarie Dyk and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African journal of emergency medicine : Revue africaine de la medecine d'urgence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Liezl SmitDepartment of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Andrew RedfernDepartment of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Sadia MurrayDepartment of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Juanita LishmanDepartment of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Marieke M van der ZalmDesmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Gert van ZylDivision of Medical Virology, Stellenbosch University, Faculty of Medicine and Health Sciences and National Health Laboratory Services, Tygerberg business unit, Cape Town, South Africa.
Lilly M VerhagenSection of Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud University Medical Center, Radboud Center for Infectious Diseases, Nijmegen, The Netherlands.
Corné de VosDepartment of Paediatric Surgery, Stellenbosch University, Cape Town, South Africa.
Helena RabieDepartment of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Annemarie DykDepartment of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Mathilda ClaassenDivision of Medical Virology, Stellenbosch University, Faculty of Medicine and Health Sciences and National Health Laboratory Services, Tygerberg business unit, Cape Town, South Africa.
Jantjie TaljaardDivision of Infectious Diseases, Department of Medicine, Tygerberg Hospital and Stellenbosch Univerisity, Cape Town, South Africa.
Marina AucampUnit for Infection Prevention and Control (UIPC), Tygerberg Hospital, Cape Town, South Africa.
Angela DramowskiDepartment of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Stellenbosch University · ZANational Health Laboratory Service · ZATygerberg Hospital · ZADesmond Tutu HIV Foundation · ZARadboud University Nijmegen · NL

Funding

The long-term consequences of pulmonary tuberculosis and respiratory viruses on lung health in young South African childrenK43TW011028 · FIC · STELLENBOSCH UNIVERSITY · PI VAN DER ZALM, MARIEKE MARGREET · 2020 to 2024
$647k
FIC NIH HHS K43 TW011028
6 · The paper itself

Abstract

Background: Identification of SARS-CoV-2 infected individuals is imperative to prevent hospital transmission, but symptom-based screening may fail to identify asymptomatic/mildly symptomatic infectious children and their caregivers. Methods: A COVID-19 period prevalence study was conducted between 13 and 26 August 2020 at Tygerberg Hospital, testing all children and their accompanying asymptomatic caregivers after initial symptom screening. One nasopharyngeal swab was submitted for SARS-CoV-2 using real-time reverse-transcription polymerase chain reaction (rRT-PCR). An additional Respiratory Viral 16-multiplex rRT-PCR test was simultaneously done in children presenting with symptoms compatible with possible SARS-CoV-2 infection. Results: SARS-Co-V 2 RT-PCR tests from 196 children and 116 caregivers were included in the analysis. The SARS-CoV-2 period prevalence in children was 5.6% (11/196) versus 15.5% (18/116) in asymptomatic caregivers ( Conclusion: Given the poor correlation between SARS-CoV-2 symptoms and RT-PCR test positivity, universal testing of children and their accompanying caregivers should be considered for emergency and inpatient paediatric admissions during high COVID-19 community transmission periods. Universal PPE and optimising ventilation is likely the most effective way to control transmission of respiratory viral infections, including SARS-CoV-2, where universal testing is not feasible. In these settings, repeated point prevalence studies may be useful to inform local testing and cohorting strategies.

Indexed as

Children and accompanying caregiversCOVID-19, Coronavirus-19SARS-CoV-2SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2Symptom screening

Identifiers

PMID35496826
PMCPMC9035358
OpenAlexW4224314518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.