Evidence map›Paper›PMID 35496774›Full record

ArticleBrain, behavior, & immunity - health2022

Imaging extra-striatal dopamine D2 receptors in a maternal immune activation rat model.

Arata Oh-Nishi, Yuji Nagai, Chie Seki, Tetsuya Suhara, Takafumi Minamimoto, Makoto Higuchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 72% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Dopamine, Immunity, and Disease.Pharmacological reviews · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Arata Oh-NishiDepartment of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, Japan.
Yuji NagaiDepartment of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, Japan.
Chie SekiDepartment of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, Japan.
Tetsuya SuharaDepartment of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, Japan.
Takafumi MinamimotoDepartment of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, Japan.
Makoto HiguchiDepartment of Functional Brain Imaging, National Institutes for Quantum Science and Technology, Chiba, 263-8555, Japan.
National Institutes for Quantum Science and Technology · JPShimane University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal immune activation (MIA) is a risk factor for schizophrenia in the offspring. MIA in pregnant rodents can be induced by injection of synthetic polyriboinosinic-polyribocytidilic acid (Poly I:C), which causes decreased striatal dopamine D2 receptor (D2R) expression and behavioral dysfunction mediated by the dopaminergic system in the offspring. However, previous studies did not determine whether Poly I:C induced cortical dopamine D2R abnormality in an MIA rat model. In this study, we performed micro-positron emission tomography (micro-PET)

Indexed as

[11C]FLB457Anterior cingulate cortexDopamineDopamine D2 receptorsIn vivo imagingMaternal immune activationMIA rat modelPoly I:CPositron emission tomographySchizophrenia

Identifiers

PMID35496774
PMCPMC9043973
OpenAlexW4220738434

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.