Evidence map›Paper›PMID 35496494›Full record

ArticleData in brief2022

Data pertaining to aberrant intracellular calcium handling during androgen deprivation therapy in prostate cancer.

Debbie O'Reilly, Tim Downing, Sana Kouba, Marie Potier-Cartereau, Declan J McKenna, Christophe Vandier, Paul Buchanan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Debbie O'ReillyDCU Cancer Research Group, DCU, Ireland.
Tim DowningSchool of Biotechnology, DCU, Ireland.
Sana KoubaDepartment of Animal Physiology, UMR INSERM U 1069, Nutrition, Growth and Cancer (N2C), University of Tours, France.
Marie Potier-CartereauDepartment of Animal Physiology, UMR INSERM U 1069, Nutrition, Growth and Cancer (N2C), University of Tours, France.
Declan J McKennaGenomic Medicine Research Group, School of Biomedical Sciences, Ulster University, N.Ireland.
Christophe VandierDepartment of Animal Physiology, UMR INSERM U 1069, Nutrition, Growth and Cancer (N2C), University of Tours, France.
Paul BuchananDCU Cancer Research Group, DCU, Ireland.
Université de Tours · FRCancer Trials Ireland · IEDublin City University · IEUniversity of Ulster · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The data generated here in relates to the research article "CaV1.3 enhanced store operated calcium promotes resistance to androgen deprivation in prostate cancer". A model of prostate cancer (PCa) progression to castration resistance was employed, with untreated androgen sensitive LNCaP cell line alongside two androgen deprived (bicalutamide) sublines, either 10 days (LNCaP-ADT) or 2 years (LNCaP-ABL) treatment, in addition to androgen insensitive PC3. With this PCa model, qPCR was used to examined fold change in markers linked to androgen resistance, androgen receptor (

Indexed as

ADT, Androgen Deprivation TherapyAndrogen deprivationAR, Androgen ReceptorCACNA1D, L-type Calcium Channel GeneCalcium channel blockerCaV1.3CaV1.3, L-type Calcium Channel ProteinCCB, Calcium Channel BlockerCRPC, Castrate Resistant Prostate CancerERG, ETS-Related GeneHPRT1, Hypoxanthine Phosphoribosyltransferase 1NSE, Neuron Specific EnolaseORAI, ORAI Calcium Release-Activated Calcium Modulator 1ORAI STIMPCa, Prostate CancerProstate cancerSERCA, Sarco(endo)plasmic Reticulum Calcium-ATPaseSOCE, Store Operated Calcium EntrySTIM1, Stromal Interaction Molecule 1Store operated calcium channelsStore operated calcium entryTg, ThapsigarginVoltage gated calcium channels

Identifiers

PMID35496494
PMCPMC9046638
OpenAlexW4224095029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.